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New applications of tetrahydropalmatine

A technology of corydalis and levocordantine, applied in the field of corydalis

Inactive Publication Date: 2010-07-14
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is still a lack of a safe and effective drug for the treatment of lung cancer in clinical practice.

Method used

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  • New applications of tetrahydropalmatine
  • New applications of tetrahydropalmatine
  • New applications of tetrahydropalmatine

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Example 1, Effect of Tetrahydropalmatine on the Proliferative Ability of Human Lung Cancer Cells

[0026] Tumor cell line: human lung cancer cell line A549 (Shanghai Institute of Cell Biology, Chinese Academy of Sciences);

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Abstract

The invention discloses new applications f tetrahydropalmatine. The new application is an application that tetrahydropalmatine shown in formula I or salts thereof which are acceptable in pharmacy are used to prepare medicines used for inhibiting the proliferation of tumor cells and an application for preparing medicines used for preventing and / or curing tumors. The result of the in vivo experiment using nude mice shows that tetrahydropalmatine can effectively inhibit the growth of tumors, and the tumor volume is much smaller than the volume of the negative control group. Therefore, tetrahydropalmatine which is widely used for analgesia has good antitumor activity, and the result shows that tetrahydropalmatine can be used to prepare medicines for curing cancers, in particular to prepare medicines for curing the lung cancer. The invention broadens the medical application field of tetrahydropalmatine.

Description

technical field [0001] The present invention relates to the new application of tetrahydropalmatine. Background technique [0002] Corydalis Corydalis is the dry tuber of Corydalis Corydalis of Papaveraceae, which has the effects of promoting blood circulation, benefiting Qi and relieving pain. Its main chemical components are alkaloids, among which tetrahydropalmatine (structural formula shown in formula I) belongs to tertiary amine alkaloids, has the strongest analgesic effect, has analgesic, sedative, sleep-promoting and stabilizing effects, especially for gastrointestinal system The dull pain induced is effective. At present, tetrahydropalmatine has been used as an over-the-counter drug for analgesia and sleep aids, such as tetrahydropalmatine sulfate tablets, Qiangtongning and so on. But there is no report on its anti-tumor aspect. [0003] [0004] Formula Ⅰ [0005] Lung cancer is a common malignant tumor of the lung, and its mortality rate has accounted for the...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61P35/00
CPCC07D471/04C07D455/03A61P35/00
Inventor 张虹金雪向俊锋李骞谭莉唐亚林
Owner INST OF CHEM CHINESE ACAD OF SCI
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