Real-time detection of vascular conditions of a subject using arterial pressure waveform analysis

A technology for detecting objects and arterial blood pressure, applied in vascular assessment, cardiac catheterization, medical simulation, etc., can solve problems such as inability to obtain central aortic pressure signals

Inactive Publication Date: 2010-08-11
EDWARDS LIFESCIENCES CORP
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Problems solved by technology

Unfortunately, proximal aortic pressure is not routinely clinically available because central aortic pr

Method used

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  • Real-time detection of vascular conditions of a subject using arterial pressure waveform analysis
  • Real-time detection of vascular conditions of a subject using arterial pressure waveform analysis
  • Real-time detection of vascular conditions of a subject using arterial pressure waveform analysis

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Embodiment Construction

[0018] The present invention describes a method of detecting the state of a subject's blood vessels. The vascular states may include different cardiovascular hemodynamic states and conditions such as, for example, vasodilation, vasoconstriction, peripheral pressure / flow decoupling, states where peripheral arterial pressure is not proportional to central aortic pressure, and The state in which peripheral arterial pressure is lower than central aortic pressure. As used herein, the term vasodilation means the state of arterial and peripheral arterial pressure and flow decoupling from central aortic pressure and flow, and the term peripheral arterial is intended to refer to arteries positioned away from the heart, such as the radial, femoral, or brachial arteries artery. Decoupled arterial pressure means that the normal relationship between arterial, peripheral arterial, and central pressure is not correct, and arterial and peripheral arterial pressure cannot be used to determine...

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Abstract

Methods for the detection of vascular conditions such as vasodilation in a subject are described. The methods involve receiving a signal corresponding to an arterial blood pressure and calculating one or more cardiovascular parameters from the arterial blood pressure. The cardiovascular parameters are calculated using factors impacted by vascular conditions such as vasodilation. Factors impacted by these vascular conditions include the area under the systolic portion of the arterial blood pressure signal, the duration of systole, and the ratio of the duration of the systole to the duration of the diastole. By monitoring cardiovascular parameters that are calculated using factors impacted by vascular conditions such as vasodilation for changes indicating the vascular conditions, such vascular conditions can be detected.

Description

Background technique [0001] Arterial blood pressure-based methods for cardiac output (CO) determination are based on the correlation between pulsatile blood flow and pulsatile pressure that exists in the arterial system. The most well-known arterial blood pressure-based systems rely on the pulse contour method (PCM), which calculates an estimate of CO from beat-to-beat characteristics of the arterial pressure waveform. In PCM, the "Windkessel" (German for "air chamber") parameters (the characteristic impedance, compliance and total peripheral resistance of the aorta) are used to construct a linear or non-linear model of aortic hemodynamics. Essentially, blood flow is analogized to the flow of current in a circuit, where impedance is in series with parallel resistors and capacitors (compliance). Stroke volume is measured, ie the theoretical pressure for cardiac output is the proximal aortic pressure. Unfortunately, proximal aortic pressure is not routinely clinically availabl...

Claims

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Application Information

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IPC IPC(8): A61B5/021
CPCG06F19/3437G16H50/50
Inventor F·哈帝布K·维利比罗L·戴德里安L·罗特里克
Owner EDWARDS LIFESCIENCES CORP
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