Stimulation, recording and administration combined device for research on use of hippocampal field potentials of mouse and rat

A combined device, rat and mouse technology, applied in the field of devices used in medical animal electrophysiology experiments, can solve the problems of low success rate of guiding field potential, time-consuming drug consumption, complicated operation, etc., so as to reduce research costs and reduce the space occupied by the device , Easy to operate and flexible effect

Inactive Publication Date: 2010-08-18
SHANXI MEDICAL UNIV
View PDF3 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problem of complex operation, high cost, time-consuming and drug-consuming, leading field To solve the technical problem of low potential success rate, provide a combination device for stimulation, recording, and administration of hippocampal field potentials in rats and mice that has a simple and compact structure, easy and flexible operation, and drugs that can be directly and quickly delivered to the recording site

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Stimulation, recording and administration combined device for research on use of hippocampal field potentials of mouse and rat
  • Stimulation, recording and administration combined device for research on use of hippocampal field potentials of mouse and rat
  • Stimulation, recording and administration combined device for research on use of hippocampal field potentials of mouse and rat

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] like figure 1 , figure 2 and image 3 As shown, a combination device for stimulating, recording, and administering drugs used in the study of hippocampal field potential in rats and mice in this embodiment includes a concentric bipolar stimulating electrode 1, a hollow unipolar recording electrode 2 made of stainless steel, and a poly The electrode fixing device 3 made of vinyl tube and the recording electrode inner core 4 made of stainless steel, wherein: the concentric bipolar stimulating electrode 1 and the hollow monopolar recording electrode 2 are fixed in the electrode fixing device 3 in parallel, and the concentric bipolar The distance a between the centers of the polar stimulating electrode 1 and the hollow monopolar recording electrode 2 is 1.0 mm, and the height difference b between the tips of the concentric bipolar stimulating electrode 1 and the hollow monopolar recording electrode 2 is 0.8 mm. In order to ensure that the stimulation / recording site of th...

Embodiment 2

[0024] like figure 1 , figure 2 and image 3 As shown, a combination device for stimulating, recording and administering drugs used in the study of rat hippocampal field potential in this embodiment has the same structure as that in Example 1, wherein the concentric bipolar stimulating electrode 1 and the hollow monopolar The distance a between the centers of the recording electrodes 2 is 0.5 mm, and the height difference b between the tips of the concentric bipolar stimulating electrode 1 and the hollow monopolar recording electrode 2 is 0.3 mm; the outer surface of the hollow monopolar recording electrode 2 The diameter is 0.5 mm and the inner diameter is 0.15 mm.

Embodiment 3

[0026] like figure 1 , figure 2 and image 3 As shown, a combination device for stimulating, recording and administering drugs used in the study of rat hippocampal field potential in this embodiment has the same structure as that in Example 1, wherein the concentric bipolar stimulating electrode 1 and the hollow monopolar The distance a between the centers of the recording electrodes 2 is 0.8 mm, and the height difference b between the tips of the concentric bipolar stimulating electrode 1 and the hollow monopolar recording electrode 2 is 0.6 mm; the outer surface of the hollow monopolar recording electrode 2 The diameter is 0.6 mm and the inner diameter is 0.2 mm.

[0027] The outer diameter of the hollow unipolar recording electrode 2 in the above embodiment can also be selected between 0.5 mm and 0.75 mm, and the inner diameter can also be selected between 0.15 mm and 0.30 mm.

[0028] The distance between the centers of the concentric bipolar stimulating electrode 1 an...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a stimulation, recording and administration combined device for the research on the use of ippocampal field potentials of mouse and rat, belonging to a device used in medical electrophysiologic experiment of animals and mainly solving the difficult technical problem that the current device has low successful rate in field potation guidance owing to complex operations and plenty of consumed time and used drugs. The technical proposal of the invention is that: a stimulation, recording and administration combined device for the research on the use of ippocampal field potentials of mouse and rat comprises an eccentric circle dual-pole stimulating electrode, a hollow single-pole recording electrode, an electrode fixation device and a recording electrode core, wherein the eccentric circle dual-pole stimulating electrode and the hollow single-pole recording electrode are arranged inside the electrode fixation device in parallel, and the recording electrode core is arranged in an administration hole in the center of the hollow single-pole recording electrode. The device further comprises an administration device consisting of a hollow administration catheter, a hose and a microinjector, wherein the upper end of the hollow administration catheter is connected with one end of the hose the other end of which is connected with the microinjector.

Description

technical field [0001] The invention relates to a stimulation, recording and administration combination device for studying hippocampal field potential of rats and mice, belonging to a device used in medical animal electrophysiology experiments. Background technique [0002] Recording in vivo / mouse hippocampal field potential is one of the important means to study advanced brain functions, and has irreplaceable physiological significance compared with isolated brain slice recording. At present, in the electrophysiological experiments of large-scale / mouse hippocampal field potential, especially long-term potentiation / depression, stimulating electrodes and recording electrodes are generally used to enter the corresponding stimulation site and recording site from different angles for electrical stimulation and field potential recording. , and observed drug-induced field potential changes in the corresponding hippocampus region by intracerebroventricular administration. The dis...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/36A61D7/00
Inventor 祁金顺王晓辉武美娜原丽王昭君李少凤潘艳芳陈小荣杨东张俊芳杨威
Owner SHANXI MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap