Hirudin polyion micelle composition of targeted platelet

A composition and technology of hirudin, applied in the field of polyionic micelle compositions, can solve the problems of changing the chemical composition of medicines and high production cost
CN101810559AInactive Publication Date: 2010-08-25PEKING UNIV
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
PEKING UNIV
Publication Date
2010-08-25
Estimated Expiration
Not applicable ยท inactive patent

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Abstract

The invention relates to a hirudin polyion micelle composition of a targeted platelet. The compound contains hirudin, arginine-glycine-aspartic acid-polyethylene glycol grafted chitosan and a polyion initiator. The polyion micelle composition can be prepared by a simple method, has platelet targeting, enhances the hirudin anticoagulation and the thrombus proofing activity, effectively suppresses the platelet aggregation and obviously improves the partial thromboplasting time of plasma.
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Description

technical field

[0001] The present invention relates to a polyionic micellar composition of arginine-glycine-aspartic acid-polyethylene glycol-chitosan (RGD-PEG-CS) loaded with hirudin targeting platelets for injection and its preparation method. Background technique

[0002] Cardiovascular and cerebrovascular diseases are one of the three major fatal diseases, among which thromboembolism is the cause of many cardiovascular and cerebrovascular diseases. Due to the induction of arteriosclerosis, vascular endothelial injury, abnormal internal and external coagulation system, or abnormal hemodynamics, the components in the blood flow process form a semi-clot-like substance on the surface of the blood vessel or the intima of the heart, which is a thrombus. Aiming at various mechanisms of thrombus formation, a variety of antithrombotic drugs have come out one after another, including drugs that inhibit thrombosis (anticoagulant and antithrombotic) and platelet aggregation (antip...

Claims

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