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Bioactive polysaccharide self-assembly modified polyurethane material and preparation method thereof

A bioactive polysaccharide and polyurethane material technology, applied in coatings, medical science, prostheses, etc., can solve problems such as infected tissue, necrosis, etc., and achieve the effects of inhibiting antibacterial activity, good hydrophilicity, and good cell compatibility

Inactive Publication Date: 2013-03-20
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The application of biological materials and artificial devices is becoming more and more widespread, but the bacterial infection caused by the use process can lead to many serious consequences that cannot be ignored, and can cause adverse reactions such as infection and tissue necrosis

Method used

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  • Bioactive polysaccharide self-assembly modified polyurethane material and preparation method thereof
  • Bioactive polysaccharide self-assembly modified polyurethane material and preparation method thereof
  • Bioactive polysaccharide self-assembly modified polyurethane material and preparation method thereof

Examples

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Effect test

Embodiment 1

[0041] A preparation method for a polyurethane material modified by bioactive polysaccharide self-assembly, comprising the steps of:

[0042] 1) Preparation of fungal polysaccharide derivative——lentinan sulfate: add 0.6g lentinan into a reaction bottle containing 50mL dimethyl sulfoxide, stir at 20°C for 12 hours, then slowly add lentinan at a rate of 2mL / min Add 9 mL of pyridine dropwise, continue to stir for 30 minutes, then place the reaction bottle in an ice bath, and slowly add 3.7 mL of chlorosulfonic acid (where chlorosulfonic acid The mol ratio with pyridine is 1: 2), then be warming up to 80 ℃ and continue stirring reaction 100 minutes, cool to room temperature after the reaction stops, be that the NaOH solution of 5wt% is adjusted pH to 7.0 with concentration (5wt% represents that in 100gNaOH solution containing NaOH 5g) to obtain a reaction solution; then inject the resulting reaction solution into a regenerated cellulose dialysis bag (36mm, Mw: 8000-14000), dialyze...

Embodiment 2

[0049] A preparation method for a polyurethane material modified by bioactive polysaccharide self-assembly, comprising the steps of:

[0050] 1) Preparation of fungal polysaccharide derivative-lentinan sulfate: add 1.2g lentinan into a reaction bottle containing 100mL dimethyl sulfoxide, stir at 30°C for 18 hours, and then slowly add lentinan at a rate of 4mL / min. Add 18 mL of pyridine dropwise, continue to stir for 40 minutes, then place the reaction bottle in an ice bath, and slowly add 7.4 mL of chlorosulfonic acid (wherein chlorosulfonic acid and The molar ratio of pyridine is 1: 2), then the temperature is raised to 80°C and the stirring reaction is continued for 120 minutes, after the reaction is stopped, it is cooled to room temperature, and the pH is adjusted to 7.0 with a concentration of 5 wt% NaOH to obtain a reaction solution; then the gained reaction solution is injected into In the regenerated cellulose dialysis bag (36mm, Mw: 8000-14000), dialyze in NaOH solutio...

Embodiment 3

[0057] A preparation method for a polyurethane material modified by bioactive polysaccharide self-assembly, comprising the steps of:

[0058] 1) Preparation of fungal polysaccharide derivative-lentinan sulfate: add 0.6g lentinan into a reaction flask containing 50mL dimethyl sulfoxide, stir at 25°C for 16 hours, and then slowly Add 18 mL of pyridine dropwise, continue to stir for 35 minutes, then place the reaction bottle in an ice bath, slowly add 3.7 mL of chlorosulfonic acid (wherein chlorosulfonic acid and The molar ratio of pyridine is 1: 2), then the temperature is raised to 80°C and the stirring reaction is continued for 120 minutes, after the reaction is stopped, it is cooled to room temperature, and the pH is adjusted to 7.0 with a concentration of 5 wt% NaOH to obtain a reaction solution; then the gained reaction solution is injected into In the regenerated cellulose dialysis bag (36mm, Mw: 8000-14000), dialyze in NaOH solution with pH 10 for 16 hours, then dialyze w...

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Abstract

The invention relates to a bioactive polysaccharide self-assembly finishing polyurethane material and a preparation method thereof. The bioactive polysaccharide self-assembly finishing polyurethane material is characterized by comprising a substrate and a finishing layer, wherein the substrate is made of a polyurethane material, and the finishing layer is prepared by finishing the surface of the substrate by using a layer-by-layer self-assembly technique; and the finishing layer contains electronegative lentinan sulfate and electropositive chitosan which are alternately self-assembled layer by layer on the surface of the substrate. The surface of the polyurethane material has favorable hydrophilicity, favorable function of resisting fibrinogen non-specific adsorption, high antibacterial activity for inhibiting Bcillus pyocyaneus and other bacteria, and favorable cell compatibility. In addition, the polyurethane material has the advantages of simple preparation technology, easy control, mild preparation conditions and low cost, and is especially suitable for preparing biomedical materials for artificial organs and devices with complicated shape and structure.

Description

technical field [0001] The invention belongs to the technical fields of biomedical materials, macromolecule chemistry and molecular self-assembly, and in particular relates to a polyurethane material modified by bioactive polysaccharide self-assembly and a preparation method thereof. Background technique [0002] Due to its outstanding physical and mechanical properties and good biocompatibility, polyurethane (PU) materials have huge applications in the field of medical polymer materials such as artificial heart valves, artificial dialysis membranes, artificial blood vessels, etc. prospect. However, when ordinary polyurethane materials are implanted as built-in medical materials, a series of adverse biological reactions will occur, such as postoperative infection, inflammatory response, thrombus and cytotoxicity, etc. These adverse reactions are all derived from non-biocompatibility reactions of synthetic materials and living environment. Therefore, it is an important dire...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/34A61L31/10A61L31/06C08J7/00C08J5/18C08J7/12C08L75/04C08B37/00
Inventor 王艺峰洪群峰熊燕飞周峰
Owner WUHAN UNIV OF TECH
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