Method for extracting succinic acid from fermentation broth

A technology of succinic acid and fermentation broth, which is applied in the separation/purification of carboxylic acid compounds, chemical industry, ultrafiltration, etc., and can solve the problem of reducing the service life of ion exchange resins, reducing the exchange capacity of ion exchange resins, succinic acid crystals and mother liquor Difficult separation and other problems, to achieve the effect of improving crystallization yield and purity, solving difficult centrifugation, and reducing energy consumption

Inactive Publication Date: 2010-08-25
凯能高科技工程(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Fermentation broth usually contains a large amount of protein, polysaccharide, colloid, etc. in addition to bacteria. These impurities will reduce the exchange capacity of the ion exchange resin and reduce the service life of the ion exchange resin. At the same time, some macromolecular impurities will flow out with succinic...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A method for extracting and separating succinic acid from fermentation broth, the method comprises the following steps:

[0049] (1) carry out ultrafiltration separation by microbial fermentation to obtain the fermentation broth of succinic acid, remove bacterial cells and macromolecular impurities, and obtain a clear and transparent filtrate;

[0050] The ultrafiltration separation adopts a tubular ultrafiltration membrane system with a membrane filtration pore size of 10-200nm (including 10nm, 50nm, 100nm, 150nm or 200nm, etc.), the operating pressure of the ultrafiltration separation is 0.4Mpa, and the operating temperature is 80°C , the concentration ratio is 40 times, and the amount of dialysis water is 4% of the volume of the fermentation broth; the ultrafiltration membrane system is mainly composed of membrane elements, pumps, transportation pipelines, and control elements, and the membrane elements are tubular stainless steel membranes. The stainless steel membr...

Embodiment 2

[0056] A method for extracting and separating succinic acid from fermentation broth, the method comprises the following steps:

[0057] (1) carry out ultrafiltration separation by microbial fermentation to obtain the fermentation broth of succinic acid, remove bacterial cells and macromolecular impurities, and obtain a clear and transparent filtrate;

[0058] The ultrafiltration separation adopts a tubular ultrafiltration membrane system with a membrane filtration pore size of 10-200nm (including 10nm, 50nm, 100nm, 150nm or 200nm, etc.), the operating pressure of the ultrafiltration separation is 0.3Mpa, and the operating temperature is 70°C , the concentration ratio is 30 times, and the amount of dialysis water is 10% of the volume of the fermentation broth; the ultrafiltration membrane system is mainly composed of membrane elements, pumps, transportation pipelines, and control elements, and the membrane elements are tubular ceramic membranes. The ceramic membrane uses alumin...

Embodiment 3

[0064] A method for extracting and separating succinic acid from fermentation broth, the method comprises the following steps:

[0065] (1) carry out ultrafiltration separation by microbial fermentation to obtain the fermentation broth of succinic acid, remove bacterial cells and macromolecular impurities, and obtain a clear and transparent filtrate;

[0066] The ultrafiltration separation adopts a plate ultrafiltration membrane system with a molecular weight cut-off of ≥10000MW (including 10000MW, 30000MW, 50000MW, 80000MW or 100000MW, etc.), the operating pressure of the ultrafiltration separation is 0.3Mpa, the operating temperature is 40°C, and the concentration ratio is 10 times, the amount of dialysis water is 15% of the volume of the fermentation broth, the ultrafiltration membrane system is mainly composed of membrane elements, pumps, conveying pipelines, and control elements, and the membrane elements are polysulfone organic polymer membranes;

[0067] (2) select H-ty...

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Abstract

The invention relates to a method for extracting succinic acid from fermentation broth. The method includes the following steps that: (1) fermentation broth from which succinic acid can be obtained by way of microbial fermentation is ultrafiltered to remove mycelium cells and macromolecular impurities, so that clear filtrate is obtained; (2) H- storng-acid cation exchange resin is chosen, the filtrate obtained in the step 1 is exchanged by the ions of the H- storng-acid cation exchange resin, so that impurity cation is exchanged by H plus, and thereby succinic acid solution is obtained; (3) the succinic acid solution obtained in the step 2 is nanofiltered and decolored, so that decolored succinic acid solution is obtained; (4) the decolored succinic acid solution obtained in the step 3 isconcentrated, crystallized, centrifuged and washed, so that succinic acid is obtained. Compared with the prior art, the invention has the advantages of reasonable process route, less steps, low energy consumption and cost, high product crystallization rate, high product purity, byproduct recyclability, energy saving and the like.

Description

technical field [0001] The invention relates to the extraction and separation of succinic acid, in particular to a method for extracting and separating succinic acid from fermentation broth. Background technique [0002] Succinic Acid (Butanedioic Acid), also known as succinic acid, is a dibasic organic acid, which is widely used as a raw material for special chemical products as a 4-carbon intermediate, such as widely used in pharmaceuticals, food processing, dyes , coatings and other industries. [0003] In recent years, succinic acid has attracted attention as a raw material for biodegradable polymers. The use of succinic acid as a raw material for biodegradable polymers and special chemicals requires high purity and low cost to avoid impurities in succinic acid that inhibit the reaction of producing final products from succinic acid or reduce the quality and competitive with other sources of succinic acid. [0004] In view of the decreasing petrochemical resources and...

Claims

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Application Information

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IPC IPC(8): C07C55/10C07C51/42C07C51/47B01D61/14
CPCY02P20/10
Inventor 曹建勇官天和
Owner 凯能高科技工程(上海)有限公司
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