High-pressure production method of 5-hydroxyl alkyl tetrazole

Abstract

The invention discloses a high-pressure production method of 5-hydroxyl alkyl tetrazole; and hydroxy alkyl nitrile, sodium azide and triethylamine react to prepare the 5-hydroxyl alkyl tetrazole under a high-temperature condition. The high-pressure production method of 5-hydroxyl alkyl tetrazole has simple process, is easy to operate, does not product wastewater and waste gas, and the product yield is high and reaches 85 percent.

Description

A kind of high-pressure production method of 5-hydroxyalkyl tetrazole Technical field: The invention relates to a high-pressure production method of 5-hydroxyalkyl tetrazole. Background technique: 5-Hydroxyalkyltetrazolium is a key intermediate for the production of new drugs by foreign companies such as BASF, and is currently mainly synthesized in small batches. 5-Hydroxyalkyltetrazolium production, the existing U.S. patent US333325 mainly uses hydroxyacetonitrile or hydroxypropionitrile, ammonium chloride and sodium azide to react in DMF solvent, and the product is obtained after post-treatment; US5284957 uses hydroxyacetonitrile Or react hydroxypropionitrile, tributyltin chloride and sodium azide in a toluene solvent, and obtain the product after post-treatment; the process is complicated, the yield is low, and there are many wastes. Invention content: The purpose of the present invention is to provide a kind of technique simple, yield is high, the production metho...

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Problems solved by technology

5-Hydroxyalkyltetrazolium production, the existing U.S. patent US333325 is mainly to react with hydroxyacetonitrile or hydroxypropionitrile, ammonium chloride and sodium azide in DMF solvent, and post-treatment to obtain the product; US5284957 is to use hydroxyacetonitrile Or hydroxypropionitrile, tributyltin chloride and sodium azide are reacted in toluene solvent, and aftertreatment obtains product; This process is complicated, yield is low, and three wastes are many

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