Pachysandra terminalis alkaloid compound for resisting tumor metastasis

An anti-tumor metastasis and alkaloid technology, applied in anti-tumor drugs, steroids, drug combinations, etc.
CN101822657AInactive Publication Date: 2010-09-08TIANJIN MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TIANJIN MEDICAL UNIV
Publication Date
2010-09-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

the invention relates to a pachysandra terminalis alkaloid compound for resisting tumor metastasis (as shown in the figure), which comprises 9-dimethylamino-4,7-megastigmadien-3-one (1), E-salignone (2), Z-salignone (3), 3beta-(3'alpha-isopropyl)-lactam-5alpha-pregn-4-one (4), pachystermine A (5), 3-spiro-(3'-oxo-isoindole)-5alpha-pregn-20-one (6) and 3beta-(methylsenecioylamino)-5alpha-pregn-20-one(7). The invention has a strong effect on resisting the chemotaxis migration of breast cancer cells, and can be used for preparing medicaments for resisting tumor metastasis.
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Description

technical field

[0001] The invention relates to an anti-tumor metastases alkaloid compound belonging to the research field of active ingredients of traditional Chinese medicines. Background technique

[0002] According to the data released by WHO, in 2005, among the 58 million total deaths in the world, the deaths caused by various tumors accounted for 13%. Tumors have become one of the major diseases that seriously threaten human health today. With the advancement of life sciences and the development of medicine, human beings' understanding of tumors has penetrated to the molecular and cellular level, and various new surgical treatment methods and chemotherapy drugs are constantly coming out. However, according to statistics from the American Institute of Cancer Research, over the past 50 years, cancer treatment has not been fundamentally improved, and cancer mortality remains high. The main reason is tumor metastasis, and there are no effective treatments and drugs for tum...

Claims

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