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Two-way filling type bioreactor control system and method

A bioreactor and control system technology, applied in the field of biomedicine, can solve problems such as dead space and blockage, and achieve the effect of facilitating realization, ensuring normal operation, and eliminating ineffective circulation

Active Publication Date: 2012-07-04
ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The primary purpose of the present invention is to provide a two-way perfusion bioreactor control system that can enhance the exchange efficiency and uniformity of the two fluids participating in the reaction when exchanging, and overcome the shortcomings of dead space and blockage when exchanging;

Method used

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  • Two-way filling type bioreactor control system and method
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  • Two-way filling type bioreactor control system and method

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Embodiment Construction

[0051] Below in conjunction with accompanying drawing and embodiment the present invention will be further described:

[0052] The biochemical reaction between the first fluid and the second fluid referred to in the present invention can occur. Among the two fluids that need to undergo biochemical reactions, after one of the fluids undergoes a biochemical reaction with the second fluid, one of them can become the target object. The target object is the object that has achieved a certain purpose of preparation or treatment. The biochemical reaction carried out, more specifically, is due to the reaction between the first (type) substance fused or present in the first fluid and the second (type) substance fused or present in the second fluid. For example, in the stage of cell culture when simulating a bioartificial liver, the medium that dissolves the cells to be cultured is perfused in the bioreactor as the first fluid, the first substance in which is the cells, and then the nut...

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Abstract

The invention discloses a two-way filling type bioreactor control system and method. One main improvement is in the bioreactor; a ligating part is used to tightly bind a filtration membrane in the bioreactor with a spindle to perform ligating so that a gap between the filtration membrane and the spindle is divided into a plurality of gap areas which are not communicated; and the other improvementis to provide a flow direction controller used for automatically switching the flow direction of a second fluid passing through the bioreactor. The invention comprehensively solves the problems of non-uniform filling, dead space, blockage and low exchange rate of the existing bioreactor.

Description

【Technical field】 [0001] The invention relates to the technical field of biomedicine, in particular to a bidirectional perfusion bioreactor control system and method. 【Background technique】 [0002] Liver failure is the end-stage manifestation of various liver diseases. Patients are in critical condition, with high mortality and poor prognosis. Liver transplantation is currently recognized as the most effective treatment method, but due to lack of donors and high technical difficulty, the widespread implementation of liver transplantation is greatly restricted. The emergence of therapeutic methods such as bioartificial liver based on in vitro cultured hepatocytes is expected to provide an effective means for the modern treatment of liver failure just as the artificial kidney once revolutionized the treatment of renal failure. However, how to rationally design new biological responses The realization of long-term large-scale culture of hepatocytes in vitro is still the bottl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/36A61M1/00
Inventor 高毅周焕城李明张志蒋泽生
Owner ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV