Antitumor drug palladium coordination compound

Abstract

The invention belongs to the field of pharmacy and relates to an antitumor drug palladium coordination compound. The palladium coordination compound has the structural formula shown in the specification, and in the formula, a ligand L is selected from aliphatic diamine or substituted aliphatic diamine, aromatic diamine and various substituted aromatic diamine, and R1 and R2 are respectively selected from substituted or unsubstituted branch, linear chain or annular aliphatic hydrocarbon, aryl group, non-aromatic family or aromatic heterocyclic groups.

Description

Technical field: The invention belongs to the field of pharmacy, and relates to a palladium complex and its application in treating cancer. Background technique: Cancer has become one of the main threats to human health, and it is showing a clear upward trend. Cancer has become the most important cause of death in the United States, and the cancer mortality rate ranks first among all causes of death in cities in my country. Therefore, my country has listed the research of anticancer drugs as one of the most important strategic issues in the development of new drugs, and researching new anticancer drugs with high efficiency, low toxicity and high selectivity has become a long-term goal and task for drug researchers. Since Rosenberg discovered that cisplatin has anticancer activity in 1969, the research and development of metal antitumor drugs has aroused widespread interest. Cisplatin has become the first metal anti-tumor drug to enter clinical use. Other platinum compound...

AI Technical Summary

Problems solved by technology

But so far, there have been no reports on the anticancer activity of nitrogen carboxylated deprotonated amino acid dianion / diamine palladium complexes at home and abroad.

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