Seabuckthorn flavone compound preparation for treating dyslipidemia

A technology of sea buckthorn flavonoids and compound preparations is applied in the field of medicine to achieve the effects of short course of treatment, comprehensive regulation of dyslipidemia, and reduction of adverse reactions

Inactive Publication Date: 2010-12-01
邬林祥 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, a single drug has not been able to reduce TC, LDL-C, TG and increase HDL-C at the same time to make blood lipids reach normal levels, so

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-25

[0013] Embodiments 1-25 are listed as follows:

[0014] In the examples, the conventional methods in the pharmaceutical industry were used, and the formulations in the following table were added to prepare tablets with pharmaceutically acceptable carriers, wherein seabuckthorn flavonoids (according to the purity of seabuckthorn flavonoids being 100%) were provided by Inner Mongolia Yuhangren Pharmaceutical Co., Ltd.

[0015] Example

[0016] 17

Embodiment 26

[0017] Example 26: Animal test on the curative effect of a seabuckthorn flavonoid compound preparation for treating dyslipidemia according to the present invention:

[0018] Purpose of the experiment: to study and compare the lipid-lowering effects of the embodiments of the present invention and the corresponding statins used alone

[0019] 1. Experimental method: 120 rats were randomly divided into groups of control group, simvastatin, and examples 14, 15, 16, and 17 of the present invention. All were fed with high-fat feed for 4 weeks, and from the fifth week, simvastatin and Examples 14, 15, 16, and 17 of the present invention were fed respectively except the control group. Venous blood samples were taken before and 8 weeks after the medication, and the total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) were determined. The results showed that the TC, LDL-C, and triglyceride (TG) of Examp...

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PUM

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Abstract

The invention discloses a seabuckthorn flavone compound preparation for treating dyslipidemia. The compound preparation consists of the following components: seabuckthorn flavone and any statin medicament. The seabuckthorn flavone compound preparation has the advantages of making full use of complementary and synergistic effect of the medicaments through combination, contribution to comprehensively regulating dyslipidemia, and reducing untoward effect related to certain dosage increase; moreover, the compound reparation is prepared by combining the active component of the natural plant medicine seabuckthorn flavone with other fat reducing chemical medicaments, and can reduce TC, LDL-C and TG, increase HDL-C and effectively regulate dyslipidemia to make the blood lipid level meet the standard. The compound preparation has the characteristics of short treatment course, quick response, small side effect and low cost.

Description

Technical field: [0001] The invention relates to a seabuckthorn flavonoid compound preparation for treating dyslipidemia, which belongs to the field of medicines. Background technique: [0002] Cardiovascular disease is one of the most common and serious diseases that endanger human health (especially middle-aged and elderly people). Dyslipidemia is an important risk factor for atherosclerosis, coronary heart disease and other cardiovascular and cerebrovascular diseases. Lipid-lowering drugs can reduce these The incidence and mortality of diseases have a positive and far-reaching impact on the prevention and treatment of cardiovascular diseases. [0003] Dyslipidemia typically includes elevated levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides and low levels of high-density lipoprotein cholesterol (HDL-C). To judge dyslipidemia, blood levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) an...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K36/185A61P3/06A61K31/22A61K31/366A61K31/40A61K31/405A61K31/47A61K31/505
Inventor 邬林祥邬林云
Owner 邬林祥
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