Novel method for adjusting time difference reaction

A technology of jet lag and reaction, applied in the fields of physiology and neurobiology, can solve problems such as physical damage and frequent night shift accidents

Inactive Publication Date: 2010-12-01
NANJING UNIV
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Problems solved by technology

The 24-hour three-shift work system adopted by many factories has greatly improved the production efficiency of the factory, but it has also brought many...

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  • Novel method for adjusting time difference reaction
  • Novel method for adjusting time difference reaction
  • Novel method for adjusting time difference reaction

Examples

Experimental program
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Embodiment Construction

[0011] 1. Construction of Maged1 knockout mice

[0012] We first replaced exons 3-8 of Maged1 with PGK-Neo on the gene targeting vector, then linearized the transformed vector, and electrotransferred it into mouse ES cells to recombine with the alleles in the ES cells , positive clones were identified by PCR and Southern, and then the positive clones were injected into the blastocysts of pseudopregnant mother mice to obtain chimeric mice. The chimeric mice were backcrossed to C57 / BL6J for more than 10 generations for the following molecular biology experiments and phenotype analysis. For specific knockout strategies, genotype identification, and protein verification results, see figure 1 .

[0013] 2. Verification of the decrease in the amplitude of the core molecular components of the circadian clock in vivo by Maged1

[0014] Mice with systemic knockout of Maged1 grew normally. We placed the Maged1 knockout littermate and the wild-type control in a 12-hour light and 12-h...

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Abstract

The invention discloses a novel method for adjusting the time difference reaction of the mammal, relating to a novel protein Magedl for adjusting the circadian rhythm and the mammal, wherein the novel protein Magedl plays an important part in maintaining the normal biological clock function. In a mouse with the Magedl, the core biological clock molecular amplitude of the mouse is changed to be small, the day-night cycle of the mouse is changed to be short, and the adjusting speed in the simulative time difference reaction is accelerated. Therefore, the Magedl can be taken as a drug target for curing the time difference reaction of human body.

Description

technical field [0001] The present invention relates to the fields of physiology and neurobiology. Specifically, the invention achieves the purpose of alleviating jet lag and enabling organisms to quickly adapt to new day and night light environments by inhibiting the activity of Maged1 molecules. Background technique [0002] With the acceleration of the pace of life in modern society and the invention of new means of transportation, people's lifestyles that have lasted for thousands of years are undergoing fundamental changes. The impact of modern lifestyles on people's physical health is also gradually emerging. [0003] Among people's various physiological processes, the impact on the circadian rhythm (that is, the biological clock that people usually say) and its consequences are particularly prominent. Circadian rhythm refers to the biological rhythm that is spontaneously maintained in the body and has a cycle close to 24 hours. It plays an important role in the org...

Claims

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Application Information

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IPC IPC(8): C12Q1/68C12N15/85A01K67/027
Inventor 唐晶谷习文王晓翰高翔徐璎
Owner NANJING UNIV
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