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PEG-coated core-shell silica nanoparticles and methods of manufacture and use

A technology of silica and nanoparticles, applied in the field of nanoparticles, can solve problems such as limited applications

Inactive Publication Date: 2010-12-01
HYBRID SILICA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Nanoscale particles can also attach non-specifically to tissues, which also limits their applications

Method used

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  • PEG-coated core-shell silica nanoparticles and methods of manufacture and use
  • PEG-coated core-shell silica nanoparticles and methods of manufacture and use
  • PEG-coated core-shell silica nanoparticles and methods of manufacture and use

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Embodiment Construction

[0016] 1. Coated CS nanoparticles

[0017] Described herein are fluorescent core-shell silica nanoparticles having one or more ligands associated with their surface. Without limitation, the following CS nanoparticles may be any of the CS nanoparticles described in U.S. Patent Publication Nos. 2004 / 0101822A1 and / or 2006 / 0245971A1. For example, a CS nanoparticle can be a silica nanoparticle with a core containing mercapto functional groups, or a silica nanoparticle with a first reference dye incorporated into the core and a second infectious dye incorporated into the shell.

[0018] CS nanoparticles can associate ligands. Ligands that can be associated with CS nanoparticles include the ligands described in U.S. Patent Publication No. 2004 / 0101822A1 and the ligands described herein. For example, ligands which may be associated with CS nanoparticles include biopolymers, synthetic polymers, antigens, antibodies, viruses or viral components, receptors, haptens, enzymes, hormones, ...

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Abstract

Described herein are PEG-coated, core-shell nanoparticles, which display reduced aggregation and / or reduced non-specific or undesired attachment characteristics. These fluorescent nanoparticle include: a silica-based core having an organic functional group that includes a mercapto substitituent, an organic fluorescent compound, a silica shell; and a silane-PEG compound. The silica shell of the nanoparticle encapsulates the silica-based core and the silane-PEG compound is conjugated to the silica shell.

Description

technical field [0001] The present application relates generally to nanoparticles, and more specifically to polyethylene glycol ("PEG")-coated fluorescent nanoparticles. In addition, the invention also describes the preparation method and application of the PEG-coated fluorescent nanoparticles. Background technique [0002] U.S. Patent Publication Nos. 2004 / 0101822 A1 and 2006 / 0245971 A1, which are incorporated herein by reference in their entirety, describe fluorescent core-shell silica nanoparticles (hereinafter "CS nanoparticles") having Various ligands attached to their surface and fluorescent dyes incorporated into their core and / or shell. In one embodiment of the CS nanoparticles, the nanoparticles are capable of emitting light in the near infrared spectral range upon excitation. Therefore, CS nanoparticles can be applied in various detection methods. For example, due to their small size and high signal output, CS nanoparticles can be part of a system in vivo, allow...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/12C09K11/02B82B1/00B32B5/16
CPCA61K49/0032C09K11/06A61K49/0093C09K11/025
Inventor U·威斯纳H·欧
Owner HYBRID SILICA TECH
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