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External preparation for skin

A skin external preparation, the selected technology, applied in the field of skin external preparations, can solve the problems of increased skin irritation, low solubility and the like

Inactive Publication Date: 2013-01-30
KAO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although it is known that rhododendron and its derivatives are ingredients that can prevent or improve skin pigmentation such as spots and freckles (see Patent Documents 1 to 3), rhododendol and its derivatives have not been used for antiseptic and anti-mold purposes.
[0007] In addition, rhododendol and its derivatives have low solubility in water; in preparations containing rhododendol and its derivatives, especially in cosmetic water with almost no viscosity, more than usual is used in order to improve the stability of the preparation. Polyoxyethylene addition nonionic surfactants act as solubilizers and must be managed in combination with lower alcohols, thus becoming a factor that increases skin irritation

Method used

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  • External preparation for skin
  • External preparation for skin
  • External preparation for skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1~24

[0085] Examples 1-24, Comparative Examples 1-6 (lotion)

[0086] According to the formulations shown in Tables 1 to 3, a lotion was prepared by a usual method, and the above-mentioned various evaluation tests were carried out. The results are also shown together.

[0087] Table 1:

[0088]

[0089] (Note 1) Ryoto Sugar Ester L-1695 (manufactured by Mitsubishi Chemical Foods Co., Ltd., HLB=16)

[0090] (Note 2) NIKKOL Decaglynl-L (manufactured by NIKKOL Chemicals Co. Ltd., HLB=15.5)

[0091] (Note 3) Sunsoft Q-12Y (manufactured by Sun Chemical Co., Ltd., HLB=17.1)

[0092] Table 2:

[0093]

[0094] table 3:

[0095]

[0096]As shown in Tables 1 to 3, the stability of the Examples of the present invention was good, but in Comparative Examples 1 to 5 that did not contain the (b) component or (c) component of the present invention, turbidity and precipitation were observed, and the stability was stable. There is a problem with sex. In addition, the Examples of the...

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PUM

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Abstract

Disclosed is an external preparation for the skin, which contains a surfactant or a preservative that is believed to be a causal substance of skin irritation in a reduced amount and therefore has low irritating properties, and also has high preparation stability. Specifically disclosed is an external preparation for the skin, which is characterized by comprising a rhododendrol represented by general formula (1) and / or a derivative thereof, a nonionic surfactant selected from a sucrose fatty acid ester and a polyglycerin fatty acid ester, and a polyhydric alcohol. The external preparation for the skin has low skin irritation properties, an excellent preservative / anti-fungal effect and high preparation stability. (In general formula (1), R represents a hydrogen atom, an acyl group having 2 to 20 carbon atoms, or a sugar residue of a monosaccharide or a disaccharide.)

Description

technical field [0001] The present invention relates to an external preparation for skin which is less irritating to skin, has excellent long-term storage stability, and has high skin beautifying and whitening effects. Background technique [0002] In external skin preparations generally formulated as cosmetics, various surfactants are used for the solubilization, emulsification, and dispersion of insoluble components; among them, they are widely used because they are safe to the skin and easy to ensure the stability of the preparation. Polyoxyethylene addition type nonionic surfactant. [0003] However, the solubility state of polyoxyethylene addition type nonionic surfactants in water and oil and their functions as surfactants are mostly affected by temperature. Since the compounding amount of the agent is set to a large amount, etc., the irritation to the skin cannot be ignored. [0004] In addition, preservatives such as p-hydroxybenzoic acid and phenoxyethanol are wid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/60A61K8/34A61K8/37A61K8/97A61K31/7028A61K36/73A61K47/10A61K47/14A61P17/00A61Q17/00A61Q19/00
CPCA61K2800/524A61K47/26A61K47/10A61K36/73A61Q19/02A61K8/60A61K31/7028A61K8/345A61K8/347A61P17/00A61K31/192
Inventor 前田沙织
Owner KAO CORP