Compositions comprising basic amino acid and soluble carbonate salt
A technology of composition and amino acid, applied in the field of compositions for cleaning oral cavity, can solve problems such as slow process
Active Publication Date: 2011-01-05
COLGATE PALMOLIVE CO
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- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
However, the efficiency of the existing process needs to be improved
First, the existing process is slow, requiring 24-48 hours to complete the reaction
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0065] A premix was prepared, which consisted of 4.26 g of heavy water (D 2 O), 0.40g L-arginine and 0.24g sodium bicarbonate, the initial pH is 9.74. The pH of the premix was adjusted to 8.99 with 34% HCl solution. The spectrum was recorded by proton NMR and revealed to be the arginine bicarbonate complex. Example 2 Prepare a premix consisting of 4.26 D 2 O, 0.40 g L-arginine, and 0.31 sodium carbonate, with an initial pH of 11.94. The pH of the premix was adjusted to 9.01 with 34% HCl solution. The spectrum was recorded by proton NMR and revealed to be the arginine bicarbonate complex.
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Abstract
This invention relates to compositions comprising a basic amino acid free or salt form and a soluble carbonate or bicarbonate salt.
Description
[0001] This application claims the benefit of US Patent Application Serial No. 61 / 027,424, filed February 8, 2008, the contents of which are incorporated herein by reference. Background of the invention [0002] Arginine and other basic amino acids have been proposed for oral care and are considered to be of significant benefit in combating caries formation and tooth sensitivity. Commercially available arginine-based toothpastes such as ProClude or DenClude , for example containing arginine bicarbonate; however, such salts are expensive. [0003] Arginine bicarbonate was prepared by bubbling carbon dioxide through saturated aqueous arginine solution. However, the efficiency of existing processes needs improvement. First, the existing process is slow, requiring 24-48 hours to complete the reaction. Second, at room temperature and normal partial pressure of carbon dioxide, the solubility of carbon dioxide in water is extremely limited, and the solution reaches a maximum co...
Claims
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IPC IPC(8): A61K8/44A61K8/37A61K8/19A61Q11/00
CPCA61K8/44A61K8/19A61Q11/00A61P1/02
Inventor R·苏布拉曼亚姆R·科利E·西蒙R·罗宾逊R·萨利文吴冬辉
Owner COLGATE PALMOLIVE CO