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Drug combination for eliminating neisseria gonorrhoeae resistance plasmids and preparation method thereof

A technology of Neisseria gonorrhoeae and composition, applied in the field of pharmaceutical composition and its preparation for eliminating drug-resistant plasmids of Neisseria gonorrhoeae, to achieve the effect of restoring sensitivity

Active Publication Date: 2011-01-12
SICHUAN ACADEMY OF MEDICAL SCI SICHUAN PROVINCIAL PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many kinds of traditional Chinese medicines that have been used in the study of mass reduction, such as atractylodes atractylodes, honeysuckle, scutellaria baicalensis, berberine, cork, Patrinia, compound Puhuang, Houttuynia cordata, comfrey, etc., but there is no traditional Chinese medicine compound that is resistant to Neisseria gonorrhoeae. A report on the study of drug plasmid elimination

Method used

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  • Drug combination for eliminating neisseria gonorrhoeae resistance plasmids and preparation method thereof
  • Drug combination for eliminating neisseria gonorrhoeae resistance plasmids and preparation method thereof
  • Drug combination for eliminating neisseria gonorrhoeae resistance plasmids and preparation method thereof

Examples

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Effect test

Embodiment 1

[0023] Recipe: Cortex Phellodendron 30g; Smilax Smilax 20g; Yellow Celery 20g.

[0024] Preparation method: A. Weigh the medicinal materials according to the formula with 10g each, and crush the medicinal materials into rice grain-sized pieces for later use; B. Add 3 times the amount of water, decoct for 20 minutes, and then separate the filter residue and the filtrate; C. Add 2 times the amount of water to the filter residue obtained in step B, decoct for 20 minutes again, and then separate the filter residue and filtrate; D, add 1 times the amount of water to the filter residue obtained in step C, and decoct again for 10 minutes Minutes, then separate the filter residue and filtrate; E, combine the filtrates obtained in steps B, C and D, vacuum filter, and concentrate at a temperature of 100°C to 33ml at a constant temperature; F, the concentrated medicinal solution obtained in step E After subpackaging, sterilize with circulating steam for 1 hour, and refrigerate at a tempe...

Embodiment 2

[0026] Recipe: Phellodendron 50g; Smilax 40g; Yellow Celery 40g.

[0027] Preparation method: A. Weigh the medicinal materials according to the formula with 10g each, and crush the medicinal materials into pieces the size of rice grains for later use; B. Add 5 times the amount of water, decoct for 40 minutes, and then separate the filter residue and filtrate; C. Add 4 times the amount of water to the filter residue obtained in step B, decoct for 40 minutes again, and then separate the filter residue and filtrate; D, add 3 times the amount of water to the filter residue obtained in step C, and decoct again for 20 minutes Minutes, then separate the filter residue and filtrate; E, combine the filtrates obtained in steps B, C and D, vacuum filter, and concentrate at a temperature of 100°C to 33ml at a constant temperature; F, the concentrated medicinal solution obtained in step E After subpackaging, sterilize with circulating steam for 1 hour, and refrigerate at a temperature of 5...

Embodiment 3

[0029] Recipe: Cortex Phellodendri 40g; Smilax Smilax 30g; Yellow Celery 30g.

[0030] Preparation method: A. Weigh the medicinal materials according to the formula with 10g each, and crush the medicinal materials into rice grain-sized pieces for later use; B. Add 4 times the amount of water, decoct for 30 minutes, and then separate the filter residue and filtrate; C. Add 3 times the amount of water to the filter residue obtained in step B, decoct for 30 minutes again, and then separate the filter residue and filtrate; D, add 2 times the amount of water to the filter residue obtained in step C, and decoct again for 15 minutes Minutes, then separate the filter residue and filtrate; E, combine the filtrates obtained in steps B, C and D, vacuum filter, and concentrate at a temperature of 100°C to 33ml at a constant temperature; F, the concentrated medicinal solution obtained in step E After subpackaging, sterilize with circulating steam for 1 hour, and refrigerate at a temperatur...

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Abstract

The invention discloses a drug combination for eliminating neisseria gonorrhoeae resistance plasmids and a preparation method thereof. The drug combination is composed of the following materials in parts by mass: 3-5 parts of golden cypress, 2-4 parts of rhizoma smilacis glabrae and 2-4 parts of radix scutellariae. The extract of the drug combination is prepared by a decoction method. The drug combination can effectively eliminate the neisseria gonorrhoeae resistance plasmids and recover sensitivity of gonococcus on antibiotics and particularly on cheap antibiotics (such as penicillin) to a certain extent, thus being of great significance to clinical application.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition capable of eliminating drug-resistant plasmids of Neisseria gonorrhoeae and a preparation method thereof. Background technique [0002] Gonorrhea is caused by Neisseria gonorrhoeae (Neisseria gonorrhoeae, referred to as NG). Although the incidence of the disease has declined in most parts of the country since 2000, according to the "2009 China Health Statistical Yearbook", gonorrhea is still at the Higher incidence level, second only to syphilis among sexually transmitted diseases. The disease has a short incubation period and strong infectivity, which can lead to many complications and sequelae, and can be concurrent and promote infection of other sexually transmitted diseases (including HIV), with serious consequences. In recent years, due to the irrational use of antibiotics, the change of the sensitivity of Neisseria gonorrhoeae to antibiotics a...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61P15/00A61P31/04
Inventor 廖菁雍刚
Owner SICHUAN ACADEMY OF MEDICAL SCI SICHUAN PROVINCIAL PEOPLES HOSPITAL