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Chitosan/ Curdlan blended membrane material and preparation method thereof

A technology of chitosan and blended membranes, which is applied in the field of medical engineering, can solve the problems of unfavorable manufacturing of artificial skin, easy occurrence of water absorption, and water absorption resistance, and achieve good blood coagulation function, high water vapor permeability, and cost reduction. Effect

Inactive Publication Date: 2012-06-13
HANGZHOU NORMAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] After searching the literature of the prior art, it was found that S. etc. published an article "New type of nanofiltration membrane based on crosslinked hyperbranched polymers" on pages 197-210 of the 2008 No. 72 issue of "Carbohydrate Polymers" (Carbohydrate Polymers) (New type of crosslinked hyperbranched polymer nanofiltration membrane ), the paper pointed out that although the chitosan film cannot permeate oxygen, the chitosan film has relatively weak resistance to water vapor, which is due to the hydrophilic effect of chitosan.
However, chitosan is prone to water absorption during placement, and this ability to absorb water is not conducive to the manufacture of artificial skin.
Srinivasa etc. article "Effect of plasticizers and fatty acids on mechanical and permeability characteristics of chitosan films" on pages 1113-1122 of the 21st issue of "Food Hydrocolloid" (food colloid) in 2007 The mechanical properties and permeability of chitosan film have been increased by adding plasticizer in the mechanical properties of chitosan film, but there is no obvious hindrance to its water absorption
So far, there have been many scientific research attempts to improve water resistance by reducing the water absorption of chitosan, but none of them are very significant.

Method used

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  • Chitosan/ Curdlan blended membrane material and preparation method thereof
  • Chitosan/ Curdlan blended membrane material and preparation method thereof
  • Chitosan/ Curdlan blended membrane material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1: the chitosan / cod gum blend film to be prepared, the specific weight percentage is: chitosan / cod gum=1 / 5, glycerin accounts for 5%, and the preparation process is as follows:

[0052] (1) Configuration of chitosan solution: Dissolve 50.00 mg of chitosan (50% deacetylation degree, 150,000 molecular weight) in 5.00 mL of 1% dilute acetic acid solution to form 10.00 mg / mL chitosan Sweet and acetic acid solution, stir well.

[0053] (2) Preparation of Curdlan solution: Dissolve 250.00 mg of Curdlan in 25.00 mL of deionized water, stir at room temperature to fully disperse Curdlan in water, and prepare a 10.00 mg / mL Curdlan aqueous solution to form a uniform and stable aqueous dispersion.

[0054] (3) Mix the two solutions in step 1) and step 2), add 11.9 μL of glycerin (ρ=1.2633g / mL), control the temperature within the range of 30°C, and stir mechanically to make the mixed solution evenly mixed to form a uniform and stable solution. of the dispersion.

[0055...

Embodiment 2

[0057] Embodiment 2: the chitosan / cod gum blend film to be prepared, the specific weight percentage is: chitosan / cod gum=1 / 1, glycerin accounts for 7.5%, and the preparation process is as follows:

[0058] (1) Configuration of chitosan solution: Dissolve 225.00 mg of chitosan (65% deacetylation degree, 400,000 molecular weight) in 15.00 mL of 3% dilute acetic acid solution to form 15.00 mg / mL chitosan Sweet and acetic acid solution, stir well.

[0059] (2) Preparation of Curdlan solution: Dissolve 225.00 mg Curdlan in 15.00 mL of 3% sodium hydroxide, stir at room temperature to fully dissolve Curdlan in the dilute alkali solution, and prepare a 15.00 mg / mL Curdlan alkali solution to form a stable solution .

[0060] (3) Mix the two solutions in step 1) and step 2), add 26.7 μL of glycerin (ρ=1.2633g / mL), control the temperature within the range of 75°C, and stir mechanically to make the mixed solution evenly mixed to form a uniform and stable of the dispersion.

[0061] (4)...

Embodiment 3

[0063] Embodiment 3: the chitosan / cod gum blend film to be prepared, the specific weight percentage is: chitosan / cod gum=2 / 1, glycerin accounts for 8.125%, and the preparation process is as follows:

[0064] (1) Configuration of chitosan solution: Dissolve 325.00 mg of chitosan (degree of deacetylation is 76%, molecular weight: 670,000) in 20.00 mL of 3.50% dilute acetic acid solution to form 16.25 mg / mL chitosan Sweet and acetic acid solution, stir well.

[0065] (2) Preparation of Curdlan solution: Dissolve 162.50 mg Curdlan in 10.00 mL of 3.5% trisodium phosphate, stir at room temperature to fully dissolve Curdlan in the dilute alkali solution, and prepare a 16.25 mg / mL Curdlan alkali solution to form a uniform stable colloidal solution.

[0066] (3) Mix the two solutions in step 1) and step 2), add 31.3 μL of glycerin (ρ=1.2633g / mL), control the temperature within the range of 90°C, and stir mechanically to mix the mixture evenly to form a uniform and stable solution. co...

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Abstract

The invention discloses a chitosan / Curdlan blended membrane material which takes chitosan and Curdlan as base materials and takes glycerol, pentaerythritol and xylitol or sorbitol as crosslinker to be prepared by a solution blending method, wherein the feeding mass ratio of chitosan to Curdlan is 1:1 / 5-5, and the feeding quality of the crosslinker is 5-10% of total mass of the chitosan and Curdlan. The chitosan / Curdlan blended membrane material of the invention can weaken the water absorption of the pure chitosan membrane and improves the air permeability of the membrane to cause the air permeability to reach higher requirements of artificial skin.

Description

(1) Technical field [0001] The invention relates to a membrane material in the technical field of medical engineering and a synthesis method thereof, in particular to a chitosan / ketan gum blend membrane material and a preparation method thereof. (2) Background technology [0002] The materials usually used to produce environment-friendly polymer membrane materials can be divided into two categories according to different sources. One is synthetic degradable polymers, such as: polycaprolactone, polylactic acid, polyvinyl alcohol and polyamide, etc.; the other is naturally occurring polymer materials, such as: chitin, chitosan, pectin , starch and cellulose etc. Naturally occurring polymer materials show promising applications due to their abundant sources, low price, and renewability. Especially in applications such as food, packaging and medical devices, it shows a superior effect than synthetic polymers. [0003] Among these many kinds of degradable membrane materials, c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L5/08C08L5/00C08K5/053C08J5/18C08J3/24A61L27/20A61L27/60
Inventor 孙燕柳永蒋子江徐杭龙王磊李伟东
Owner HANGZHOU NORMAL UNIVERSITY
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