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Application of methazolamide to preparation of medicament for treating plateau fatigue

A methazolamide and anti-fatigue technology, which is applied in the application field of methazolamide in the preparation of anti-fatigue drugs in plateau hypoxic environments, and can solve problems such as complex sources of origin and difficulty in forming a quality control system

Inactive Publication Date: 2011-02-16
ARMY MEDICAL UNIV
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Problems solved by technology

Therefore, the origin of Rhodiola rosea is relatively complicated, and it is difficult to form a unified quality control system
At present, there is no research and application report on the impact of methazolamide on human labor ability at high altitude, that is, anti-fatigue at high altitude

Method used

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  • Application of methazolamide to preparation of medicament for treating plateau fatigue
  • Application of methazolamide to preparation of medicament for treating plateau fatigue
  • Application of methazolamide to preparation of medicament for treating plateau fatigue

Examples

Experimental program
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Embodiment Construction

[0020] The animal experiment process and results are as follows:

[0021] Animals and grouping: In the present invention, Kunming mice are used as test objects. 180 mice were randomly divided into 6 groups according to body weight, namely normoxia control group, hypoxia control group, methazolamide 0.3 times normal dose group, methazolamide normal dose group, and methazolamide 5 times normal dose group. Dose group and methazolamide 10 times the normal dose group, 30 rats in each group. 0, 0, 0.312mg / kg, 0.937mg / kg, 4.687mg / kg, 9.375mg / kg of methazolamide acetazolamide were administered every day, and the intragastric volume was 0.5ml. Except for the normoxia control group, the other five groups were fed in a hypobaric chamber equivalent to an altitude of 5,000 meters above sea level, and were taken out for 1 hour a day for gavage, and the control group was given the same volume of triple-distilled water, and the indicators were measured after 10 days of continuous gavage . ...

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Abstract

The invention relates to the application of methazolamide to the preparation of an anti-fatigue medicament taken under a plateau low-oxygen environment. The anti-fatigue medicament which is prepared from the methazolamide and taken under the plateau low-oxygen environment has the effects of enhancing exercise tolerance, delaying the occurrence of fatigue and accelerating fatigue elimination under the plateau environment and has the advantages of convenient source, small taking dose and small toxic or side effect.

Description

technical field [0001] The invention relates to the use of a compound in medicine, in particular to the use of methazolamide in the preparation of anti-fatigue medicines in plateau hypoxic environments. Background technique [0002] my country is the country with the largest plateau area, the highest altitude, and the largest population in the world. With the implementation of the Western Development Strategy and the needs of economic development, national defense construction, mountain tourism, and scientific investigation, more and more people are going to the plateau. However, the natural environment of the plateau is harsh, and low air pressure and low oxygen partial pressure seriously affect human health. There are two main impacts: one is various altitude sickness, which is life-threatening in severe cases; exercise fatigue. Altitude sickness can occur in a resting state, and can be divided into acute altitude sickness and chronic altitude sickness. Among them, acute...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P39/00A61K31/433
Inventor 张钢周思敏高钰琪田怀军黄庆愿
Owner ARMY MEDICAL UNIV
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