Preparation process of H1N1 influenza virus inactivated antibody plasma for treating and producing raw material

Abstract

The invention discloses a preparation process of H1N1 influenza virus inactivated antibody plasma for treating and producing a raw material. Continuous pressure circulation plasma virus inactivation technology and low-temperature refrigeration are performed for three times by a physical method, so that viruses such as a human immunodeficiency virus (HiV), a hepatitis B virus (HBV), a hepatitis C virus (HCV), a cytomegalovirus (CMV) and the like which comprise variants and possibly exist in the plasma can be inactivated effectively, active ingredients and antibody protein of the plasma can be kept better, virus inactivation effect is definite, safety is high, active lymphocytes possibly remaining in the plasma can be killed effectively, blood transfusion safety can be ensured and a blood transfusion adverse reaction can be prevented. Simultaneously, a pressure circulation plasma virus inactivation process can be in gapless junction with a plasma sampling process, so that operation can be simplified, consumptive materials are saved, energy consumption is lowered, cost is lowered and the process is economical and practical and is convenient to popularize. If the process is used for inactivating viruses of raw material plasma, a subsequent production process can be simplified, production period can be shortened and production cost can be lowered.

Description

technical field [0001] The invention relates to a preparation process of inactivated antibody plasma, in particular to treatment and production of raw materials for A H 1 N 1 Preparation process of influenza virus inactivated antibody plasma. Background technique [0002] Type A H 1 N 1 Influenza virus antibody plasma is in the AH 1 N 1 Plasma products and preparations for specific immunotherapy in the treatment of critically ill patients with influenza. The plasma was obtained from the tested AH 1 N 1 Influenza survivors or influenza A H 1 N 1 Obtained from the collection of influenza vaccine recipients. At present, institutions that collect and supply plasma currently prepare influenza A H 1 N 1 In the operating procedures for influenza virus antibody plasma, there is a lack of process steps for inactivating the plasma virus, but the collected influenza A H that has not been treated for virus inactivation 1 N 1 Influenza virus antibody plasma is used for direc...

AI Technical Summary

Problems solved by technology

The plasma was obtained from the tested AH 1 N 1 Influenza survivors or influenza A H 1 N 1 Obtained from the collection of influenza vaccine recipients. At present, institutions that collect and supply plasma currently prepare influenza A H 1 N 1 In the operating procedures for influenza virus antibody plasma, there is a lack of process steps for inactivating the plasma virus, but the collected influenza A H that has not been treated for virus inactivation 1 N 1 Influenza virus antibody plasma is used for direct infusion, so that there may be potential risks and safety hazards of "window period" virus infection such as HiV, HBV, HCV, etc.