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Agents for maturing, normalizing or stabilizing blood vessels and wrinkle-preventing and improving agents

A stabilizer, mature technology, applied in the field of vascular maturation, normalization or stabilizer, and wrinkle prevention and/or improvement agent, capable of solving problems such as excessive production of angiogenesis-promoting factors, endothelial cell damage, etc.

Active Publication Date: 2011-02-23
SHISEIDO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the above-mentioned abnormal blood vessels can be triggered by the following reasons: changes in blood flow and internal and external environmental factors caused by diabetes, hyperlipidemia, hypertension, etc. cause damage to endothelial cells and / or parietal cells (cell death, etc.); or cancer and and / or inflammation causing overproduction of angiogenesis-promoting factors

Method used

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  • Agents for maturing, normalizing or stabilizing blood vessels and wrinkle-preventing and improving agents
  • Agents for maturing, normalizing or stabilizing blood vessels and wrinkle-preventing and improving agents
  • Agents for maturing, normalizing or stabilizing blood vessels and wrinkle-preventing and improving agents

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] The composition of embodiment 1;

[0058] (Ingredient) Compounding amount (mass%)

[0059] Cinnamon Twig Extract 1.0

[0060] Ethanol for cosmetic use 30.0

[0061] Purified water balance

Embodiment 2

[0062] The composition of embodiment 2;

[0063] (Ingredient) Compounding amount (mass%)

[0064] HP-20 column 50% ethanol dissolution fraction of cassia twig extract 1.0

[0065] Ethanol for cosmetic use 30.0

[0066] Purified water balance

[0067] Scoring: Judgment Benchmarks

[0068] 0: Wrinkles are not observed.

[0069] 1: Wrinkles are shallower, shorter or fewer in number than score 2.

[0070] 2: Shallow wrinkles are observed.

[0071] 3: Wrinkles are deeper or longer than score 2. And compared with score 4, the wrinkles are shallower, shorter or fewer in number.

[0072] 4: Light wrinkles are observed as a whole.

[0073] 5: Compared with score 4, wrinkles are deeper or longer. And compared to score 6, the wrinkles are shallower or shorter.

[0074] 6: Deep and long wrinkles are observed.

[0075] 7: Compared with score 6, deep and long wrinkles increased. And compared to score 8, the wrinkles are shallower or shorter.

[0076] 8: Deep and long wrinkles are...

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Abstract

Provided are agents for maturing, normalizing or stabilizing blood vessels, or Tie-2-activating agents made from extracts of Cinnamomum sp. plants.

Description

technical field [0001] The present invention provides a vascular maturation, normalization or stabilization agent, Tie2 (tyrosine containing Ig and EGF homology domain containing) extract derived from plants of the genus Cinnamomum, particularly plants of the species Cinnamomum cassia Blume. Tyrosine Kinase with Ig and EGF Homology Domain 2) activator (Tie2 phosphorylating agent) and wrinkle preventing and / or improving agent. Background technique [0002] In blood vessels, vascular smooth muscle cells and / or pericytes, which are collectively called vascular wall cells, originate from the luminal surface of vascular endothelial cells and adhere to vascular endothelial cells via an extracellular matrix or directly. The adhesion ratio between endothelial cells and mural cells is different according to the diameter of blood vessels. In a large vessel system, one layer of endothelial cells is attached to multiple layers of mural cells. In medium and small blood vessels, one endot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61Q19/08A61K36/18A61P9/14A61K8/97A61P17/00A61P43/00
CPCA61K36/54A61K8/97A61Q19/08A61K8/9789A61K8/9794A61P3/10A61P9/00A61P9/10A61P9/12A61P9/14A61P17/00A61P17/02A61P19/02A61P19/06A61P29/00A61P31/04A61P35/00A61P37/02A61P37/08A61P43/00
Inventor 大田正弘小林孝次草苅健常长诚高仓伸幸
Owner SHISEIDO CO LTD
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