Multi-mode targeted probe for early hepatic fibrosis diagnosis and preparation method thereof
A liver fibrosis, multi-mode technology, applied in the field of multi-mode targeting probes and its preparation, to achieve the effects of improving water solubility, reducing steric hindrance, and prolonging circulation time
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0045] Such as figure 1 Shown is the synthetic route map of the multimodal targeting probe of the present invention, the synthetic steps of the synthetic route map of the multimodal targeting probe (Den-RGD) are as follows:
[0046] 1. Synthesis of c(RGDyK):
[0047] The present invention synthesizes c(RGDyK) (MW=619.68Da) with Fmoc-protected solid-phase polypeptide synthesis method:
[0048] (1) Weigh 0.4g of resin-Gly (Fmoc-Gly-2-Cl-Trt, degree of substitution 0.6mmol / g, about 0.25mmol), wash and swell with dichloromethane (DCM) for 20 minutes, wash with DMF (N , N-dimethylformamide) and washed several times.
[0049] (2) Deprotection with 20% piperidine (DMF: piperidine = 2ml: 0.5ml) for 2 consecutive times, 10-15 minutes each time. DMF washed several times.
[0050] (3) Weigh 1.25 mmol of the required amino acid, add 0.18 g of HOBt (1-hydroxybenzotriazole), and use 2.45 ml of HBTU (benzotriazole-N, N, N', N'-tetra Methylurea hexafluorophosphate) and 0.44ml of DIEA (N,...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com