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Synthetic method of cefquinome sulfate

A technique for the synthesis of cefquinome sulfate and its synthetic method, which is applied in the new synthesis process of antibiotic raw materials for animals, and in the field of synthesis of cefquinome sulfate, which can solve problems such as unsatisfactory product purity and color, harsh reaction conditions, and difficult separation and purification. , to achieve the effect of cheap raw and auxiliary materials, high product yield, and easy access to raw and auxiliary materials

Active Publication Date: 2012-04-04
AMICOGEN CHINA BIOPHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It effectively solves the problems of harsh reaction conditions, complex reaction system, difficult separation and purification, and unsatisfactory product purity and color in the original process route.

Method used

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  • Synthetic method of cefquinome sulfate
  • Synthetic method of cefquinome sulfate
  • Synthetic method of cefquinome sulfate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Preparation of 7-phenylacetamido-3-[(5,6,7,8-tetrahydroquinoline)methyl]-cephalosporanic acid p-methoxybenzyl halide (7)

[0036] 10 g of GCLE and 3.75 g of KI were added to 50 ml of dichloromethane, and the reaction was stirred at room temperature for 3-5 hours (reaction monitored by TLC). Cool down to below -10°C, add dropwise a mixture of 5,6,7,8-tetrahydroquinoline / dichloromethane 2.67g / 15ml, stir for 3 hours, add 80ml isopropyl ether dropwise, precipitate a solid, and filter with suction , washed, and dried in vacuo to obtain compound 11.05g with a yield of 92%, and the purity was detected by HPLC (≥80%).

[0037](2) Preparation of 7-amino-3-[(5,6,7,8-tetrahydroquinoline)methyl]-cephalosporanic acid halide (8)

[0038] Add 10g of compound (7) (unrefined) to 50ml of dichloromethane, stir, cool to 0°C, add 2.1ml of pyridine dropwise, after the addition is complete, cool down to -10°C, add dropwise 5.6g of phosphorus pentachloride / 30ml Dichloromethane solution, ...

Embodiment 2

[0042] (1) Preparation of 7-phenylacetamido-3-[(5,6,7,8-tetrahydroquinoline)methyl]-cephalosporanic acid p-methoxybenzyl halide (7)

[0043] 10 g of GCLE and 3.75 g of KI were added to 40 ml of acetone, and the reaction was stirred at room temperature for 3-5 hours (reaction monitored by TLC). Cool down to below -10°C, add dropwise a mixture of 5,6,7,8-tetrahydroquinoline / acetone 2.67g / 25ml, stir for 3 hours, add 80ml of isopropyl ether dropwise, precipitate a solid, suction filter, and wash , dried in vacuo to obtain compound 11.13g, the yield was 92.7%, and the purity was detected by HPLC (≥80%).

[0044] (2) Preparation of 7-amino-3-[(5,6,7,8-tetrahydroquinoline)methyl]-cephalosporanic acid halide (8)

[0045] Add 10g of compound (7) (unrefined) to 50ml of dichloromethane, stir, cool to 0°C, add 3.27ml of triethylamine dropwise, after addition, cool down to -10°C, add 5.6g of phosphorus pentachloride dropwise / 50ml of dichloromethane solution, temperature control -10 ℃ fo...

Embodiment 3

[0067] (1) Preparation of 7-phenylacetamido-3-[(5,6,7,8-tetrahydroquinoline)methyl]-cephalosporanic acid p-methoxybenzyl halide (7)

[0068] Add 10g of GCLE and 3.75g of KI to 40ml of dichloromethane, stir and react at room temperature for 3 to 5 hours (reaction monitored by TLC), cool down to below -10°C, add 5,6,7,8-tetrahydroquinone dropwise Phenyl / acetone 2.67g / 21ml (g:V) mixed solution was stirred for 3 hours, 80ml of isopropyl ether was added dropwise, a solid was precipitated, filtered with suction, washed, and dried in vacuo to obtain 11.38g of compound with a yield of 94.8%, detected by HPLC Purity (≥80%).

[0069] (2) Preparation of 7-amino-3-[(5,6,7,8-tetrahydroquinoline)methyl]-cephalosporanic acid halide (8)

[0070] Add 10g of compound (7) (unrefined) to 50ml of dichloromethane, stir, cool to 0°C, add 3.27ml of triethylamine dropwise, after addition, cool to -10°C, add dropwise 5.6g of phosphorus pentachloride / 45ml dichloromethane solution, and kept at -10°C f...

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Abstract

The invention relates to the field of chemical synthesis, particularly to a novel synthetic process of an antibiotic material drug special for animals, in particular to a novel synthetic method of cefquinome sulfate. The method comprises the following steps of: taking GCLE (7-Phenylacetamide-3-chlorormethyl-3-cepham-4-carboxylic acid p-meth-oxybenzyl ester) as a starting material, and reacting with 5,6,7,8-tetrahydroquinoline after chlorine is replaced by iodine in C-3 chlorine methyl; by preparing an intermediate (7), successively stripping C-7 amino protection and C-4 carboxyl protection under the action of phosphorus pentachloride and phenol; reacting with AE-active ester in the existing of triethylamine; and preparing cefquinome sulfate. The method effectively solves the problems of stringent requirements of reaction condition of an original process route, complicated reaction system, difficult separation and purification, low purity and bad tincture of products and the like. The method has the advantages of simple technology, mild reaction condition, high yield, low cost and high quality and is suitable for industrialized production; and raw auxiliary materials have low priceand are easily obtained.

Description

technical field [0001] The present invention relates to the field of chemical synthesis, in particular to a new synthesis process of animal-specific antibiotic raw materials, in particular to a new synthesis method of cefquinome sulfate Background technique [0002] Cefquinome is a fourth-generation animal-specific cephalosporin antibiotic developed by Hearst in the 1980s. It was first approved for marketing in 1993. It has broad antibacterial spectrum, strong antibacterial activity, fast absorption, low toxicity, and low residue. It is a national second-class new veterinary drug. In order to overcome the shortcomings of the previous three generations of cephalosporin antibiotics, which are highly effective against Gram-positive bacteria and relatively weak against Gram-negative bacteria, the fourth-generation cephalosporin antibiotic cefquinome for animals has the characteristics of fast absorption, short peak time, and biological Features of high utilization. In view of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D501/46C07D501/06
Inventor 王玲张振安李树英李建国杜希兵
Owner AMICOGEN CHINA BIOPHARM CO LTD
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