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Application of catalpol in preparing drug for treating cardiac failure disease

A heart failure, drug technology, applied in cardiovascular system diseases, drug combinations, pharmaceutical formulations, etc., can solve problems such as damage to organs, toxic side effects, etc.

Inactive Publication Date: 2011-04-13
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these types of drugs are widely used in clinical practice, they all have different degrees of toxic and side effects and damage various organs of the human body. Therefore, it is urgent to develop a new class of safe and efficient Chinese medicines.

Method used

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  • Application of catalpol in preparing drug for treating cardiac failure disease
  • Application of catalpol in preparing drug for treating cardiac failure disease
  • Application of catalpol in preparing drug for treating cardiac failure disease

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0015] Preparation Example 1: Preparation of Catalpol Injection

[0016] Weigh 25.0g of catalpol raw material, dissolve in 1000ml of water for injection, fully stir to dissolve, add water for injection to 2000ml, add 2.5g of activated carbon for needles, heat to 60°C and stir for 30 minutes, filter with carbon rod, and filter the filtrate through 0.25μm Sterilize by filtration with a microporous membrane, pack in 1000 vials, with a filling volume of 2.0ml / bottle, seal, and sterilize. Each bottle contains catalpol 20mg. The adult body weight is based on 60kg, and the clinical dosage of catalpol injection for adults is 0.8mg / kg / d of catalpol.

preparation example 2

[0017] Preparation example 2: Preparation of catalpol freeze-dried powder injection

[0018] Weigh 25.0g of catalpol raw material and 50.0g of medicinal mannitol, dissolve in 1000ml of water for injection, stir well to dissolve, add water for injection to 2000ml, add 2.5g of activated carbon for needles, heat to 60°C and stir for 30 minutes, carbon Rod filtration, the filtrate is sterilized by filtration through a 0.25 μm microporous membrane, divided into 1000 vials, the filling volume is 2.0ml / vial, freeze-dried, and obtained. Each bottle contains catalpol 20mg.

experiment example 4

[0034] Experimental Example 4 Catalpol Acute Toxicity Test

[0035] Get 20 healthy KM mice, 18-22g, half male and half male, inject catalpol maximum amount 8mg / 20g (mouse body weight) into the tail vein, after a single administration, observe the abnormal reaction that occurs in the animal within 7 days, the death situation and cause of death. Results: After the catalpol injection was injected into the tail vein of the mice, the activity of the tested animals decreased significantly within 2 hours after the administration, and the general condition was good during the observation period thereafter, with no decrease in activity, no decrease in food intake, and no loose stools . The animals were sacrificed 7 days later, and no pathological changes visible to the naked eye were found on dissection. The test results show that the maximum administration dose of catalpol for mouse tail vein injection is 400mg / kg, and the catalpol is made into traditional Chinese medicine injection...

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Abstract

The invention relates to an application of catalpol in preparing a drug for treating cardiac failure diseases, namely a new application of reacted catalpol in the field of pharmacodynamic activity. The catalpol has the effect of resisting the cardiac failure. In the invention, a traditional Chinese medicine injection prepared by the catalpol is applied to treating the cardiac failure diseases.

Description

technical field [0001] The present invention relates to the use of catalpol, in particular to the new use of catalpol in the field of pharmacological activity. Background technique [0002] Catalpol is an unstable iridoid glycoside compound, which mainly exists in plants such as Rehmannia glutinosa, and has a wide range of pharmacological effects. Catalpol is an effective component of Rehmannia glutinosa for lowering blood sugar, and has anti-cancer, neuroprotective, anti-inflammatory, anti-hepatitis virus and diuretic effects. At present, there is no application of catalpol in the preparation of drugs for the treatment of heart failure. [0003] Catalpol is colorless needle crystal, molecular formula: C 15 h 22 o 10 ; Molecular weight: 362.33; Melting point: 206°C. Its structure is as formula 1: [0004] [0005] Formula 1 [0006] Congestive Heart Failure (CHF) is a clinically common cardiovascular disease syndrome with high mortality and high medical costs. Ofte...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/04
Inventor 陈龙彭国平徐浩坤王中越
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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