Application of Chinese medicinal composition in preparation of medicament for treating diabetic cardiomyopathy

A composition and technology of traditional Chinese medicine are applied in the application field of traditional Chinese medicine composition in the preparation of drugs for treating diabetic cardiomyopathy, and can solve the problems of inconsistent treatment and prognosis of patients and the like

Active Publication Date: 2011-05-04
HEBEI YILING MEDICINE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, although modern medical treatment has made some progress in improving the prescription of Xinliaigui, the effect on the treatment and prognosis of patients is still inconsistent, and the combined treatment of traditional Chinese medicine shows obvious advantages

Method used

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  • Application of Chinese medicinal composition in preparation of medicament for treating diabetic cardiomyopathy
  • Application of Chinese medicinal composition in preparation of medicament for treating diabetic cardiomyopathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Embodiment 1: the preparation of medicine capsule of the present invention

[0062] prescription:

[0063] Astragalus 450g Aconite 112.5g Ginseng 225g Salvia miltiorrhiza 225g Tinglizi 150g

[0064] Xiangjia skin 180g Alisma 225g safflower 90g Polygonatum 75g Chenpi 75g

[0065] Guizhi 90g

[0066] Preparation:

[0067] (1) Radix Astragali, Tinglizi, Alisma, Ginseng, and Cyperus bark were extracted twice according to the above prescription with 8 times the amount (weight ratio) of 70% ethanol under reflux, the first time was 3 hours, the second time was 2 hours, and combined The extract is filtered, and the filtrate is decompressed to recover ethanol, concentrated to 60°C to measure the clear paste with a relative density of 1.25-1.30, and set aside;

[0068] (2) Guizhi and tangerine peel are distilled to extract volatile oil according to the proportion, the aqueous solution after oil extraction is filtered, and set aside, and the residue is decocted with 8 times th...

Embodiment 2

[0072] Embodiment 2: the preparation of active ingredient

[0073] prescription:

[0074] Astragalus 450g Aconite 112.5g Ginseng 225g Salvia miltiorrhiza 225g Tinglizi 150g

[0075] Xiangjia skin 180g Alisma 225g safflower 90g Polygonatum 75g Chenpi 75g

[0076] Guizhi 90g

[0077] Preparation:

[0078] 1) Extract astragalus, Tinglizi, Alisma, ginseng or Codonopsis pilosula, Xiangjia bark or Anwujia bark with 70% ethanol, filter, concentrate the extract to a clear paste with a relative density of 1.25-1.30 at 50-70°C ;

[0079] 2) Extract the volatile oil of cassia twig and tangerine peel with water to obtain volatile oil A, aqueous solution B, and medicinal dregs C;

[0080] 3) Add water to decoct aconite, salvia miltiorrhiza, polygonatum odoratum, and safflower, and filter the resulting aqueous solution to obtain filtrate D;

[0081] 4) Filtrate the aqueous solution B after extracting volatile oil from cassia twigs and tangerine peel, collect the aqueous filtrate E, ad...

Embodiment 3

[0084] Embodiment 3: the preparation of pharmaceutical tablet of the present invention

[0085] prescription:

[0086] Astragalus 150g Aconite 40g Ginseng 225g Salvia 225g Tinglizi 50g

[0087] Xiangjiapi 180g Alisma 75g Polygonatum 75g Guizhi 30g Safflower 90g Chenpi 25g

[0088] Preparation:

[0089] (1) Radix Astragali, Tinglizi, Alisma, Ginseng, Cyperus bark were extracted twice according to the above prescription plus 8 times the amount of 70% ethanol under reflux, the first time was 3 hours, the second time was 2 hours, the extracts were combined, filtered After that, the filtrate is mixed with the alcohol extraction paste of step (1), and dried at 65-70°C;

[0090] (2) Guizhi and tangerine peel are distilled to extract volatile oil according to the prescription amount, the aqueous solution after oil extraction is filtered, and set aside, and the residue is decocted with 8 times the amount of water for 1 hour, filtered, and the decoction is combined, set aside;

[00...

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Abstract

The invention discloses application of a Chinese medicinal composition in preparation of a medicament for treating diabetic cardiomyopathy. The Chinese medicinal composition consists of 11 gouts of Chinese medicaments such as astragalus, ginseng, root of red rooted salvia and the like. The medicaments for tonifying qi and warming yang are used as radical components for treating channels and strengthening heart, and the medicaments for promoting blood circulation and removing obstruction in channels are used as auxiliary medicaments, so the qi is vigorous, the blood is activated, the channels are dredged, and blood stasis and channel obstruction are blocked. Experiment researches prove that the Chinese medicinal composition can effectively treat the diabetic cardiomyopathy.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition, in particular to an application of a traditional Chinese medicine composition in the preparation of medicines for treating diabetic cardiomyopathy. Background technique [0002] Diabetic cardiomyopathy is one of the main complications of diabetes. It is a unique cardiomyopathy characterized by cardiac hypertrophy, myocardial fibrosis, defects in calcium transport at the cellular level, myocardial contractile protein collagen formation, and abnormal fatty acid metabolism. In the early stage, there may be left ventricular diastolic dysfunction, which is often manifested clinically as cardiac insufficiency, without obvious atherosclerosis and hypertension. Among diabetic patients without previous medical history of heart disease and hypertension, up to 40% of diabetic patients will have the characteristics of left ventricular hypertrophy and decreased diastolic funct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61P9/00A61P3/10
Inventor 丁来标
Owner HEBEI YILING MEDICINE INST
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