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Traditional Chinese medicine composition for treating sexual precocity of children and preparation and quality detection method thereof

A composition and technology of traditional Chinese medicine, applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve the problems of unacceptable, easy to cause social problems, expensive medicine, etc., and achieve the treatment of early sexual precocious puberty Effect

Active Publication Date: 2011-05-11
SHANGHAI CHILDRENS HOSPITAL
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

At the same time, CPP causes early puberty in children, and their intelligence and psychology are immature, which can easily lead to social problems; therefore, CPP is increasingly concerned by families and society, and it is of great significance to actively explore effective treatment methods and carry out early intervention
[0003] At present, the gonadotropin-releasing hormone agonist (GnRHa) recommended internationally for the treatment of precocious puberty in girls has a positive effect, but it should generally be treated continuously for several months to several years, until it is close to the age of puberty So far, the drug is expensive and cannot be accepted by most families of children in China; progesterone hormone therapy is also used to reduce the level of sex hormones and subside sexual syndrome, but it is ineffective for delaying bone maturation and controlling bone growth acceleration, so it cannot prevent Short stature, clinically rarely used alone

Method used

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  • Traditional Chinese medicine composition for treating sexual precocity of children and preparation and quality detection method thereof
  • Traditional Chinese medicine composition for treating sexual precocity of children and preparation and quality detection method thereof
  • Traditional Chinese medicine composition for treating sexual precocity of children and preparation and quality detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0059] Experimental example 1: Research experiment of extraction process

[0060] 1. Orthogonal experimental design for volatile oil extraction

[0061] 1.1 Weigh 120g of angelica, 180g of turmeric, 120g of tangerine peel, 120g of Cyperi cyperi, 120g of Bupleurum and other medicinal materials, crush the medicinal materials such as angelica, turmeric, tangerine peel, Cyperus cyperi and Bupleurum into coarse powder, and then fully mix them to extract volatile oil ,, select L 9 (3 4 ) orthogonal experiment to optimize it, and select extraction time (A), soaking time (B), and water addition (C) as the investigation factors. The inspection index is the amount of volatile oil extracted, and the results are visually analyzed and analyzed by variance.

[0062] Table 1 Factor level table of orthogonal test for extraction of volatile oil

[0063]

[0064] Table 2 volatile oil extraction process L 9 (3 4 ) orthogonal table

[0065]

[0066]

[0067] Table 3 Variance analy...

experiment example 2

[0097] Experimental Example 2: Experimental Research on the Content Determination of Baicalin in Traditional Chinese Medicine Composition

[0098] 1. Solution preparation

[0099] Reference substance solution: take baicalin reference substance, add methanol to make a 0.3mg / ml solution, and use it as the reference substance solution.

[0100] Test solution: Accurately measure 2ml of the traditional Chinese medicine composition, put it in a 25ml measuring bottle, add an appropriate amount of methanol, shake fully in a water bath, cool to room temperature, add methanol to constant volume, shake well, filter, and take the subsequent filtrate as the test product solution.

[0101] 2. Chromatographic conditions

[0102] Take 1ul each of the reference substance solution and the test solution respectively, and spot on the same polyamide film, using acetic acid as the developer. Unfold and remove to dry. Determination by thin-layer scanning method, wavelength: λs = 323nm, λR = 500nm,...

Embodiment 1

[0114] Embodiment 1: the preparation of Chinese medicine composition

[0115] 100 parts by weight of Cortex Moutan, 100 parts by weight of Gardenia, 100 parts by weight of Bupleurum

[0116] Poria cocos 210 parts by weight Melon betel skin 100 parts by weight Angelica sinensis 100 parts by weight

[0117] Guang Yujin 210 parts by weight, Chenpi 100 parts by weight, Fritillaria 100 parts by weight

[0118] 700 parts by weight of raw oysters, 100 parts by weight of cortex, and 100 parts by weight of Cyperus

[0119] 100 parts by weight of Scutellaria baicalensis 100 parts by weight of triangular root 100 parts by weight of Atractylodes macrocephala

[0120] 100 parts by weight of Radix Paeoniae Alba, 3 parts by weight of sodium benzoate, 0.5 parts by weight of total steviol glycosides

[0121] 2 parts by volume of lemon essence.

[0122] The raw materials of the traditional Chinese medicine composition, angelica, turmeric, tangerine peel, Cyperi cyperi, and Bupleurum chinens...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating liver depression and phlegm stagnation type sexual precocity of children and a preparation method and quality detection method thereof, belonging to the field of traditional Chinese medicine. The traditional Chinese medicine composition oral solution for treating sexual precocity of children is prepared based on the traditional Chinese medicine theory from the following traditional Chinese medicinal materials: radix scutellariae, root-bark of peony, cape jasmine, radix bupleuri, tuckahoe, trichosanthes bark, angelica sinensis, radix curcumae, dried orange peel, thunberg fritillary bulb, raw oyster, phellodendron bark, nutgrass galingale rhizome, burreed tuber, white atractylodes rhizome, white peony root and the like. The traditional Chinese medicine composition has the efficacies of soothing the liver, regulating the flow of qi, reducing fever, promoting blood circulation, softening hard masses and resolving phlegm, and is suitable for treating the liver depression and phlegm stagnation type sexual precocity of children. The traditional Chinese medicine composition can effectively suppress premature and fast development of the sexual gland and quick epiphyseal arrest, slows down the growth speed of skeletal age, maintains normal growth speed of children and improves the eventual body height of children. The traditional Chinese medicine composition has no obvious toxic or side effect after being taken by children, and has low price, good social effect and economic benefit and wide market development prospect, and the responses of children and parents are generally good.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating precocious puberty of children with liver stagnation and phlegm obstruction type, a preparation method and a quality detection method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Child Precocious Puberty (CPP) is a common endocrine disease in children. It is an abnormal phenomenon of growth and development. An endocrine disorder in which bisexuality, or menarche occurs before the age of 10 in girls. Epidemiological surveys found that the prevalence of precocious puberty among children in Shanghai is about 1000 / 100,000, and the ratio of male to female is about 1:5. And due to various reasons, the incidence rate has been increasing year by year in recent years. The disease is mainly due to the neuroendocrine dysfunction of the hypothalamus leading to early activation and hyperfunction of the hypothalamic-pituitary-gonadal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066G01N30/90A61P5/24A61K35/56A61K35/618
Inventor 李江奇胡斯王申东姚国英沈阳李嫔张武标刘兆康
Owner SHANGHAI CHILDRENS HOSPITAL
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