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General flavone extractive of four medicaments including grassleaf sweetflag rhizome and preparation method thereof

A calamus four flavors and extract technology, applied in the preparation, detection and application fields of calamus four flavors total flavonoids extract, can solve the problems of unseen flavonoids extraction and its preparation method and use

Active Publication Date: 2012-07-25
董玉 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Calamus four flavors mainly contain flavonoids, phenylpropanoids, anthraquinones, alkaloids, terpenes and other ingredients, but so far there is no patent related to the extraction of flavonoids in calamus four flavors, its preparation method and use

Method used

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  • General flavone extractive of four medicaments including grassleaf sweetflag rhizome and preparation method thereof
  • General flavone extractive of four medicaments including grassleaf sweetflag rhizome and preparation method thereof
  • General flavone extractive of four medicaments including grassleaf sweetflag rhizome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Embodiment 1: Preparation of calamus four-flavored flavonoids extract

[0095] Take 1.5kg of calamus four-flavor compound medicinal herb pieces, reflux extraction with 10L of 50% ethanol for 3 times, extract for 1 hour each time, recover the solvent under reduced pressure to obtain the extract, add a certain volume of water to disperse and dissolve, so that the amount of medicinal materials is equal to the volume of the solution after dispersion The ratio is 1:3.5. Through 7.5LAB-8 macroporous adsorption resin, the adsorption flow rate is 2Bv / h, the diameter-to-height ratio of the resin column is 1:10, and 1.5 times the resin volume is eluted with water for impurity removal, the impurity removal flow rate is 2Bv / h, and 50% ethanol is eluted 8 times the volume of the resin, the elution flow rate is 2Bv / h, collect the 50% ethanol eluate, recover the solvent, dry under reduced pressure, and obtain the calamus four-flavored flavonoids extract.

Embodiment 2

[0096] Embodiment 2: Preparation of calamus four-flavored flavonoids extract

[0097] Take 0.5 kg of calamus four-flavor compound medicinal herb decoction pieces, add 70% ethanol and 15 L ultrasonic extraction for 3 times, extract for 1.5 hours each time, recover the solvent under reduced pressure to obtain the extract, add a certain volume of water to disperse and dissolve, so that the amount of medicinal materials is the same as that of the dispersed solution The volume ratio is 1:5. Through 10L AB-8 macroporous adsorption resin, the adsorption flow rate is 2Bv / h, the diameter-to-height ratio of the resin column is 1:6, and the water is eluted to 2 times the volume of the resin for impurity removal. The impurity removal flow rate is 4Bv / h, and 50% ethanol is eluted 7 times the volume of the resin, the elution flow rate is 1Bv / h, collect the 50% ethanol eluate, recover the solvent, dry under reduced pressure, and obtain the calamus four-flavored flavonoids extract.

Embodiment 3

[0098] Embodiment 3: Preparation of calamus four-flavored flavonoids extract

[0099] Take 1.2 kg of calamus four-flavor compound medicinal herb decoction pieces, reflux extraction with 7% ethanol twice, the amount of solvent is 10 parts by volume, and extract for 2.5 hours each time, recover the solvent under reduced pressure to obtain the extract, add water to disperse and dissolve, so that the amount of medicinal materials is the same as that after dispersion The volume ratio of the solution is 1:10, through the 90-mesh polyamide equivalent to 7 volume times of the crude drug amount, the adsorption flow rate is 2BV / h, the diameter-to-height ratio of the polyamide column is 1:10, and the water elution of 3 times the volume of the polyamide, the flow rate 4BV / h; 70% ethanol of 7 times the volume of polyamide is eluted, the elution flow rate is 7BV / h, the 70% ethanol eluate is collected, the solvent is recovered, and dried under reduced pressure, which is the Acorus siwei flavo...

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Abstract

The invention provides a method for preparing and detecting a general flavone extractive of four medicaments including grassleaf sweetflag rhizome. The general flavone extractive of four medicaments including grassleaf sweetflag rhizome is prepared from the following raw medicinal materials in parts by weight: 200-600 parts of galangal, 100-300 parts of purpurea halitum, 50-150 parts of elecampane and 50-150 parts of grassleaf sweetflag rhizome. The preparation method of the general flavone extractive from the four medicaments including the grassleaf sweetflag rhizome can be prepared by adopting any one of the following methods or any combination of the methods: (1) a solvent extraction method; (2) a macroporous absorption resin method; (3) a polyamide method; and (4) a supercritical CO2 fluid extraction method, wherein the preferable methods include the macroporous absorption resin method and the polyamide chromatography method.

Description

technical field [0001] The invention relates to a Mongolian medicine, in particular to the preparation, detection and application of a calamus four-flavor total flavonoid extract. Background technique [0002] The four flavors of calamus are composed of galangal, purple sand, woody, and calamus. They are commonly used in Mongolian medicine. The traditional Mongolian medicine theory believes that the four flavors of calamus have the functions of relieving "Badaganheyi", relieving asthma and relieving pain. . For the treatment of diaphragm spasm, chest tightness, shortness of breath, sternocostal tingling, indigestion. Calamus four flavors mainly contain flavonoids, phenylpropanoids, anthraquinones, alkaloids, terpenes and other components, but so far no patents related to the extraction of flavonoids in calamus four flavors and their preparation methods and uses have been seen. Contents of the invention [0003] The purpose of the present invention is to provide a prepara...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9062A61P21/02A61P11/00A61P29/00A61P1/14A61P11/06A23L1/29A61K33/14A23L33/00
Inventor 董玉马强
Owner 董玉