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Topically applied composition containing povidone iodine and mometasone furoate

A technology of mometasone furoate and povidone-iodine, which is applied in directions such as medical preparations containing active ingredients, pharmaceutical combinations, organic active ingredients, etc., can solve the problems of difficulty in production and use, poor stability, and short validity period of preparation products. , to achieve the effect of avoiding slow elimination, high stability, and overcoming the contraindication of skin inflammation

Inactive Publication Date: 2011-06-01
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application specification shows that the composition made of corticosteroid micropowder and povidone-iodine has poor stability, resulting in a short validity period of the preparation product, which is difficult to meet the requirements of production and use

Method used

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  • Topically applied composition containing povidone iodine and mometasone furoate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of embodiment 1 mometasone furoate aqueous suspension

[0043] Mometasone furoate 0.1g Polyvinylpyrrolidone 5g Povidone iodine 10g

[0044] Water for injection to 1000g

[0045] Water phase preparation: take the prescribed amount of mometasone furoate, povidone iodine, and polyvinylpyrrolidone, dissolve in 500ml of water, stir or sonicate until uniform, and add to the prescribed amount of water to obtain. Mometasone furoate%=0.01%, povidone-iodine%=1%, the obtained suspension can be divided into spray bottles to make nasal spray

Embodiment 2

[0046] The preparation of embodiment 2 mometasone furoate aqueous suspension

[0047] Mometasone furoate 0.5g Polyvinylpyrrolidone 10g Povidone-iodine 30g

[0048] Water for injection to 1000g

[0049] Prepared according to the method of Example 1, to get final product. Mometasone furoate%=0.05%, povidone-iodine%=3%

[0050] The resulting suspension is dispensed into spray bottles to make a nasal spray

Embodiment 3

[0051] The preparation of embodiment 3 mometasone furoate aqueous suspension

[0052] Mometasone furoate 1g Polyvinylpyrrolidone 10g Povidone iodine 50g

[0053] Water for injection to 1000g

[0054] Prepared according to the method of Example 1, to get final product. Mometasone furoate%=0.1%, povidone-iodine%=5%

[0055] The resulting suspension is dispensed into spray bottles to make a nasal spray

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Abstract

The invention relates to a topically applied composition containing povidone iodine and mometasone furoate, in particular to a topically applied pharmaceutical composition which contains the micronized mometasone furoate, the povidone iodine and one or more physiologically acceptable excipients applicable to topical application; and in the pharmaceutical composition, the content of the povidone iodine is 1%-10%, and the content of the mometasone furoate is 0.01%-0.1%.

Description

Technical field: [0001] The invention relates to a topical pharmaceutical composition with povidone iodine and glucocorticoid as active ingredients. Background technique: [0002] Skin inflammations such as eczema, allergic dermatitis, atopic dermatitis, and urticaria are all allergic reactions caused by certain allergens, resulting in skin inflammation and skin allergies There are many kinds of allergens that react, among which infections such as viruses, fungi, and bacteria are one of the important causes of skin inflammation, Yuan Wei et al. Journal, February 2004, 24-25) disclosed that 96 of 136 patients with atopic dermatitis were diagnosed with fungal infection, and the literature believed that fungal infection was an important cause of various skin inflammations such as allergic dermatitis. sensitive factors. Glucocorticoids are widely used to treat skin inflammation. However, due to the immunosuppressive effect of glucocorticoids, when glucocorticoids are used to t...

Claims

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Application Information

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IPC IPC(8): A61K31/79A61K31/58A61P29/00A61P11/02A61P17/00A61P31/00A61P37/08
Inventor 孙亮陈松赵琳
Owner TIANJIN JINYAO GRP
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