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Benzaconine transdermal gel having effects of relieving pain and resisting inflammation

A technology of benzoylaconitine and benzoylaconitum, which is applied in the field of medicine, can solve problems such as safety concerns, strong toxic effects, and application restrictions, and achieve improved safety, reduced toxicity, and obvious and precise pharmacological effects Effect

Inactive Publication Date: 2011-06-08
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although aconitine has so many physiological effects, due to its strong toxic effect, the lethal dose for humans is only about 4 mg, so raw aconitine used as medicine has brought great safety concerns to people, and its application has been greatly restricted. Therefore, my country is very cautious about the research on new drugs and modified formulations containing toxic medicinal materials such as raw aconitum

Method used

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  • Benzaconine transdermal gel having effects of relieving pain and resisting inflammation
  • Benzaconine transdermal gel having effects of relieving pain and resisting inflammation
  • Benzaconine transdermal gel having effects of relieving pain and resisting inflammation

Examples

Experimental program
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Effect test

Embodiment 1

[0044]

[0045] Mix and stir Carbomer and water according to the formula shown above (percentage by weight), add the dissolved low-concentration NaOH solution into the above liquid and stir to prepare a gel matrix, dissolve the drug with glycerin and ethanol and add it together with the penetration enhancer Stir well in the gel to make a gel.

Embodiment 2

[0047]

[0048] Mix and stir Carbomer and distilled water according to the formula shown above (percentage by weight), add the dissolved low-concentration NaOH solution into the above liquid and stir to prepare a gel matrix, dissolve the drug in glycerin and ethanol and add it together with the penetration enhancer Stir well in the gel to make a gel.

Embodiment 3

[0050]

[0051] Mix and swell hydroxypropylmethylcellulose and water (pH5.5) according to the formula (weight percentage) shown above, mix and stir the drug and PEG to dissolve and stir the menthol evenly, mix the above solution with the swollen matrix and stir evenly , made into a gel.

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Abstract

The invention relates to a benzaconine transdermal gel having effects of relieving pain and resisting inflammation. The gel comprises the following components in percentage by weight: 0.1 to 10 percent of benzaconine, 2 to 30 percent of transdermal penetrating agent, 60 to 95 percent of solvent and 1 to 20 percent of gel matrix. The gel is prepared by dissolving the benzoyl aconine transdermal, the transdermal penetrating agent and the solvent in the gel matrix. The benzaconine keeps the biological activities of relieving the pain and resisting the inflammation of aconitine, the toxicity is obviously reduced, medicaments can directly reach lesion sites through transdermal medicament delivery, and the safety is further improved. The benzaconine and the aconitine have basically consistent transdermal penetrating behaviors, can be directly penetrated into skin and have quick response. Animal medicinal effect tests in which the benzaconine is prepared into the gel show that the gel has obvious and exact pharmacological effects of relieving the pain and resisting the inflammation.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a benzoylaconitine transdermal gel with analgesic and anti-inflammatory effects. Background technique [0002] Aconitum is an important traditional Chinese medicinal material. Traditionally, raw aconitum (Aconitum aconitum, Aconitum aconitum, etc.) is used in external preparations, while processed products of aconitum (Aconitum, etc.) are used in oral administration, mainly because people think that raw aconitum The analgesic effect is strong and the toxicity is high, and the physiological activity of aconitum is small but the toxicity is low. Therefore, raw aconitum is suitable for external use and processed aconitum is suitable for internal use. Raw aconitine contains various diester-type alkaloids, including aconitine, mesoaconitine and hypoaconitine (see Figure 1), all of which have different degrees of physiological activity. [0003] [0004] [0005] Figure 1 St...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/439A61P29/00
Inventor 汪晴孙玉明张晴
Owner DALIAN UNIV OF TECH
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