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Technology and method for preparing novel combined formulation of jade-screen powder

A technology of Yupingfeng powder and production method, which can be applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc., can solve the problem of less new substances, and achieve the effect of strong sustained and controlled release performance and wide target distribution.

Inactive Publication Date: 2011-06-22
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in most cases, due to the small amount of the new substance, it only plays a synergistic or auxiliary effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Prepare the following raw materials by the aforementioned method:

[0044] Extracts, nanoparticles, microcapsules, nanoparticles.

[0045] The composition of the raw materials used to make the active ingredients is——

[0046] 10 parts of Radix Astragali, 10 parts of Atractylodes Rhizome, 5 parts of Fangfeng.

[0047] Its manufacturing process is as follows:

[0048] In the GMP10000 clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed according to the ratio of 4:2:2:2, and the latest version of the "Chinese Pharmacopoeia" preparation part of the hard capsule standard is adopted, without adding excipients, antiseptic The preparation is filled with hard capsules by a full-automatic capsule filling machine to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant sterilization, and issue a steriliz...

Embodiment 2

[0050] Prepare the following raw materials by the aforementioned method:

[0051] Water decoction concentrate, nanoliposome, nanoemulsion, microemulsion, nanosuspension.

[0052] The composition of the raw materials used to make the active ingredients is——

[0053] 10 parts of Radix Astragali, 10 parts of Atractylodes Rhizome, 5 parts of Fangfeng.

[0054] Its manufacturing process is as follows:

[0055] In the GMP10000 clean room, the decoction concentrate, nanoliposome, nanoemulsion, microemulsion, and nanosuspension are mixed according to the ratio of 5:1:1:2:1, and the latest version of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch...

Embodiment 3

[0057] Prepare the following raw materials by the aforementioned method:

[0058] Extract, solid lipid nanoparticles, nanoemulsion.

[0059] The composition of the raw materials used to make the active ingredients is——

[0060] 10 parts of Radix Astragali, 10 parts of Atractylodes Rhizome, 5 parts of Fangfeng.

[0061] Its manufacturing process is as follows:

[0062] In the GMP10000 clean room, the extract, solid lipid nanoparticles, and nanoemulsions are mixed in a ratio of 4:3:3, and the latest version of the "Chinese Pharmacopoeia" preparation part of the film standard is adopted, and the film-forming material is polyvinyl alcohol. Made into a film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The area of ​​each film is 2-40 square centimeters, the drug content is 1.2-5 grams, and each film is applied fo...

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PUM

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Abstract

The invention relates to a technology and a method for preparing a novel combined formulation of jade-screen powder. The novel combined formulation of jade-screen powder comprises the following active ingredients in part by weight: 10 parts of astragalus, 10 parts of large headed atractylodes and 5 parts of ledebouriella root. The production process comprises the steps of: ethanol-water extraction, ultrasonic grinding extraction, microwave extraction, decocting concentration, supersonic spray drying, high-pressure homogenization, nano grinding, preparation of nano particles and the like. The invention has the advantages of emphasizing on the multiple synergism, multi-targeting action and the like of nano Chinese medicaments. When the technology and the method are used for industrial mass production, the production cost is greatly lowered, the product quality is improved, and the targeting property and the slow control-released property of the medicament are higher; and the medicament can be pasted on the human skin after being prepared into films, and the active ingredients can be absorbed through the skin for treatment.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Yupingfeng powder, and also relates to a preparation technology of a new integrated dosage form of Yupingfeng powder and a production method thereof. Background technique [0002] The relevant laws and regulations on drug management in my country stipulate that changing dosage forms is managed as a new drug research. [0003] There are few research reports on compound targeted preparations and controlled release preparations of traditional Chinese medicine. The compatibility of traditional Chinese medicine compound can change the pharmacokinetic parameters of active ingredients or part preparations, which proves the scientific connotation of the compatibility of traditional Chinese medicine compound from the level of pharmacokinetics. Traditional Chinese medicine compound prescription embodies the holistic view, system theory, and syndrome differentiation and treatmen...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61K9/00A61P11/00A61P11/02A61P11/06A61P13/12A61P17/00A61P37/08
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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