Compound ceftiofur sodium freeze-dried power injection used for injection

A technology of ceftiofur sodium and freeze-dried powder injection, which is applied in the field of compound ceftiofur sodium freeze-dried preparations for injection, can solve the problems of bacterial resistance and high cost, and achieve the purpose of inhibiting the rise of body temperature and PGF-A concentration , wide antibacterial spectrum and high stability

Active Publication Date: 2012-07-18
QILU ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the problems of bacterial drug resistance and high cost of the existing animal-specific cephalosporin antibiotic ceftiofur sodium, the inventor provides a compound ceftiofur sodium freeze-dried powder injection for injection, which can solve the problem of bacterial infection. The drug resistance of ceftiofur sodium is beneficial to reduce the cost, and at the same time, it can also reduce the damage of existing drugs to animal kidneys and endotoxin pyrogen reaction

Method used

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  • Compound ceftiofur sodium freeze-dried power injection used for injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Control the temperature at 10±5°C, add 1 part by weight of sulbactam sodium and 1 part by weight of flunixin meglumine into the sterile container, add water for injection to 85% of the total amount, and open the vacuum (make the system slightly negative). Press), stir to dissolve, then add 2 weight parts of ceftiofur sodium to the above solution, turn on the vacuum, stir to dissolve, adjust the pH value to 4.5~6.5, add water for injection to the full amount, and stir evenly.

[0019] Samples were taken to measure the pH value and the content of ceftiofur sodium, sulbactam sodium, and flunixin meglumine. After the test indicators were qualified, first filter with a 0.45 μm cellulose filter, and then filter with a 0.22 μm cellulose filter. Remove impurities.

[0020] The filtered filtrate is divided into control glass bottles, half-stoppered, and vacuum freeze-dried to prepare the compound ceftiofur sodium freeze-dried powder injection of the present invention.

Embodiment 2

[0022] Control the temperature at 10±5°C, add 4 parts by weight of ceftiofur sodium into a sterile container, add water for injection to 85% of the total amount, turn on the vacuum, stir to dissolve, then mix 1 part by weight of sulbactam sodium and 1 Part by weight of flunixin meglumine was added to the above solution, opened the vacuum, stirred to dissolve, adjusted the pH value to 4.5-6.5, added water for injection to the full amount, and stirred evenly.

[0023] Samples were taken to measure the pH value and the content of ceftiofur sodium, sulbactam sodium, and flunixin meglumine. After the test indicators were qualified, first filter with a 0.45 μm cellulose filter, and then filter with a 0.22 μm cellulose filter. Remove impurities.

[0024] The filtered filtrate is divided into control glass bottles, half-stoppered, and vacuum freeze-dried to obtain the compound ceftiofur sodium / sulbactam sodium freeze-dried powder injection of the present invention.

[0025] For the a...

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Abstract

The invention is a compound ceftiofur sodium freeze-dried power injection used for injection, and the compound ceftiofur sodium freeze-dried power injection provided by the invention is mainly composed of the following effective components in parts by weight: 2-4 parts of ceftiofur sodium, 1 parts of sulbactam sodium and 1 parts of flunixin meglumine; a vacuum freeze drying method is adopted to prepare the effective components into the compound ceftiofur sodium freeze-dried power injection used for injection. The compound ceftiofur sodium freeze-dried power injection has the advantages that the preparation cost can be lowered, and the drug resistance of bacteria on the ceftiofur sodium is relieved; and the broad antimicrobial spectrum is wide, the activity is strong, the drug administration times is less, and low stress and slight side effect are endured; and the negative effect of endotoxin can be effectively blocked.

Description

Technical field: [0001] The invention belongs to the field of animal medicines, in particular to a freeze-dried preparation of compound ceftiofur sodium for injection. Background technique: [0002] Ceftiofur Sodium is the first third-generation cephalosporin antibiotic for livestock and poultry created by Pharmacia & Upjohn in the United States. The drug acts on transpeptidase to block the synthesis of bacterial cell wall and exhibits bactericidal effect. It has strong antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and some anaerobic bacteria. It has clinical antibacterial effect on common livestock and poultry pathogens such as Actinobacillus pleuropneumonia and Pasteurella multocida pneumonia. better. Since it was approved by the FDA for the treatment of cattle respiratory infections in 1988, it has been widely used in veterinary clinical treatment at home and abroad because of its excellent antibacterial activity and in vivo kinetics. Co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/546A61K31/43A61K31/44A61K9/19A61P31/04
Inventor 李成应王海挺董丽黄娟吴连勇田玉柱
Owner QILU ANIMAL HEALTH PROD
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