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Compound preparation for treating spinal cord injury and preparation method thereof

A compound preparation and spinal cord injury technology, applied in the field of traditional Chinese medicine preparations, can solve the problems of insignificant and expensive drugs, and achieve the effects of quality assurance, improvement of neurological function, and low treatment cost

Inactive Publication Date: 2011-06-29
李泽兵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drugs currently used are expensive and have little effect. In recent years, with the continuous improvement of medicine and rehabilitation technology, more patients with spinal cord injury not only survived the initial injury, but lived a fulfilling life and lived to old age.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] According to the composition ratio: Ganoderma lucidum: 50%, Yuanshen 15%, Danpi 2.8%, licorice and rice kernel in appropriate amount, and the rest are auxiliary materials. Soak Ganoderma lucidum, Yuanshen, Danpi, Licorice and rice kernels in water. After fully moistening, add 6 times and 4 times the amount of water respectively, and decoct twice, the first time for 2 hours, and the second time for 1 hour. Filter the decoction, combine the filtrates, and concentrate to an appropriate amount. Add 2 times the amount of 95% ethanol, stir well, and place it for more than 24 hours. Take the supernatant, recover ethanol until there is no alcohol smell, add 50g of sucrose and 2g of benzoic acid, stir well, add water to make 1000ml, and pack it separately.

Embodiment 2

[0031] Proportion according to the composition: 60%, ginseng 22%, cortex paeonol 3.5%, licorice and rice kernel in appropriate amount, and the rest as auxiliary materials. Soak Ganoderma lucidum, Yuanshen, Danpi, Licorice and rice kernels in water. After fully moistening, add 6 times and 4 times the amount of water respectively, and decoct twice, the first time for 2 hours, and the second time for 1 hour. Filter the decoction, combine the filtrates, and concentrate to an appropriate amount. Add 2 times the amount of 95% ethanol, stir well, and place it for more than 24 hours. Take the supernatant, recover ethanol until there is no alcohol smell, add 50g of sucrose and 2g of benzoic acid, stir well, add water to make 1000ml, and pack it separately.

Embodiment 3

[0032] Embodiment 3: The effect of this compound preparation in rabbit experimental spinal cord injury repair

[0033] 45 New Zealand white rabbits, half male and half male, were randomly divided into compound preparation treatment group (group A), control group (group B) and sham operation group (group C), with 15 rabbits in each group. Among them, the first two groups used the modified Allen's heavy object impact method to make the rabbit spinal cord injury model. In group A, the compound preparation was injected immediately after spinal cord injury; in group B, plasma was injected immediately after spinal cord injury; in group C, only simple laminectomy was performed. The spinal cord evoked potential (SSEP) was detected on the 1st, 3rd, 17th, and 24th day after operation in each component and each group; the spinal cord myelin basic protein (MBP) was detected on the 3rd, 7th, and 14th day after operation.

[0034] The results show,

[0035] SSEP detection:

[0036] 1. De...

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PUM

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations, and relates to a compound preparation for treating spinal cord injury and a preparation method thereof. The compound preparation provided by the invention is prepared from Chinese herbal medicines such as lucid ganoderma, radix scrophulariae, root bark of the peony tree, licorice root, coix seed and the like, and the compound preparation is used for treating spinal cord injury and assisting the rehabilitation of patients with spinal cord injury. Clinical practices prove that the compound preparation provided by the invention can obviously improve the functional statuses of injured spinal nerves, assist the function rehabilitation of articulations of limbs, and improve the state of urinary incontinence; and the compound preparation can effectively treat cervical spondylosis myelopathy and lumbocrural pains.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to a compound preparation of traditional Chinese medicines, in particular to a compound preparation for treating spinal cord injury and a preparation method thereof. Background technique [0002] Paralysis caused by spinal cord injury is a serious disability. It is reported that 20-30 new cases of spinal cord injury occur per million people every year in various countries, mostly young adults. The etiology is traumatic and non-traumatic, and traumatic spinal cord injury is more common. Spinal cord injury mainly has the following complications: neurological dysfunction, hemiplegia, paraplegia, quadriplegia, bladder incontinence, urinary incontinence, limb dysfunction, etc., which brings huge disasters to patients and increases the social burden. The drugs currently used are expensive and have little effect. In recent years, with the continuous improvement of me...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61P25/00
Inventor 李泽兵
Owner 李泽兵
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