Bee pollen water extract for treating female premature ovarian failure and preparation method and application thereof

Abstract

The invention provides a bee pollen water extract for treating female premature ovarian failure and a preparation method and application thereof, relating to the technical field of processes for extracting active substances from angiospermous bee pollen. The preparation method comprises the following steps of: firstly performing wall breaking on the bee pollen at low temperature, soaking the bee pollen in water of normal pressure and temperature, performing ultrasonic extraction, removing solid impurities, taking water soluble substances of the bee pollen, and finally performing ultrafiltration at the ambient temperature of -5 to 5 DEG C to separate the active components with the molecular weight below 4800D, namely the bee pollen water extract for treating premature ovarian failure. The bee pollen water extract can be used for preparing an oral preparation for treating premature ovarian failure, and the oral preparation is convenient to use and has good absorbing effect and low price, and can be used for general health care of women for preventing occurrence of premature ovarian failure; and the bee pollen water extract also can be used for preparing an injection preparation for treating premature ovarian failure, and the injection preparation can be absorbed rapidly and has strong treatment pertinence. The bee pollen water extract provided by the invention has an obvious effect on treating premature ovarian failure and has no side effects and low cost, and the preparation method and application of the bee pollen water extract are simple and easy to implement.

Description

technical field [0001] The invention relates to the technical field of water extraction of effective substances from plants, especially angiosperm bee pollen. Background technique [0002] Premature ovarian failure (POF) refers to the failure of ovarian function in women with normal development before the age of 40 for some reason. It is manifested as secondary amenorrhea, low estrogen and high gonadotropin state, which is customarily called early menopause. The incidence rate of premature ovarian failure before the age of 40 is about 1% to 3%, while the incidence rate within the age of 30 is 0.1%. Current studies suggest that the reserve of primordial germ cells is a key factor in determining the length of a woman's reproductive life, and the formation of primordial germ cells is controlled by multiple genes. In addition to being regulated by innate genetic factors, the maintenance of ovarian function in mature women is also affected by a variety of acquired factors. So f...

AI Technical Summary

Problems solved by technology

Bee pollen is rich in proteins, amino acids, unsaturated fatty acids, polysaccharides, vitamins, dietary fiber, enzymes, flavonoids, nucleic acids, natural hormones and other nutrients and biologically active substances. At the body level, it exerts the pharmacological effects of estrogen-like and anti-androgen, and makes the premature ovary reverse nearly normal, but there are not many studies on what substances in bee pollen work

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