Heparin-free anticoagulant infection inhibitor for hemodialysis and preparation method thereof

A technology of heparin blood and preparations, applied in the directions of antitoxins, antifungals, antivirals, etc., can solve the problems of increasing toxic side effects, adverse reactions and the risk of drug-resistant bacteria, increasing medical expenses, etc., and reaching the applicable population of the product Wide, suitable for a wide range of people, no toxic and side effects

Inactive Publication Date: 2011-07-20
王啸龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] (3) Risk of dialysis infection: Prevention of infection is a safeguard measure for dialysis treatment. Dialysis has the risk of infection, and antibiotics are often used for prevention, which not only increases medical expenses, but also increases the risk of toxic and side effects, adverse reactions, and drug-resistant bacteria
Since methemoglobin is easy to combine with CN- (cyano group) to form cyanide hemoglobin, but the two dissociate after a few minutes, so it can only temporarily inhibit the toxicity of CN- to tissue poisoning

Method used

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Embodiment approach

[0019] 1. The standards and requirements of raw materials, auxiliary materials, excipients and utensils used in the present invention must meet or exceed the standards or relevant requirements of the People's Republic of China according to their use.

[0020] 2. The manufacturing conditions of the present invention should meet or reach the standards or relevant requirements of the competent department of the People's Republic of China or the region where it is located.

[0021] 3. The purpose of the present invention can be achieved by the following scheme: sodium citrate: 1 part; methylene blue: 0.001 to 0.8 parts; chondroitin sulfate: 0.001 to 10 parts; use the above substances in proportion with other auxiliary materials and excipients Mix to make preparations.

[0022] 4. The consumption of the three main raw materials of the present invention is determined according to their dose-effect relationship, synergistic relationship, auxiliary materials, and excipients. If the ab...

Embodiment 1

[0027] 6.0 grams of sodium citrate, 3.0 grams of chondroitin sulfate, 0.3 grams of methylene blue, 0.35 grams of ethyl p-hydroxybenzoate, 2 milliliters of medicinal ethanol, and up to 100 milliliters of water for injection. Dissolve sodium citrate and chondroitin sulfate in about 80 ml of water first to obtain liquid A, dissolve ethyl p-hydroxybenzoate in 2 ml of ethanol to obtain liquid B, add drops of liquid B to liquid A under constant stirring, and then add U.S. Blue, add water for injection to 100 ml, fill and sterilize in a 10 ml ampoule to obtain the finished product.

Embodiment 2

[0029]6.6 g of sodium citrate, 1.5 g of chondroitin sulfate, 0.5 g of methylene blue, 0.2 g of methyl p-hydroxybenzoate, 0.05 g of propyl p-hydroxybenzoate, 0.5 g of sodium pyrrolidone carboxylate, add about 60 ml of water for injection and stir Dissolve, add water for injection to 100 ml until uniform, fill and seal in a 20 ml ampoule, sterilize, and package with a sterile hemodialysis infusion tube to obtain a finished product.

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Abstract

The invention relates to a heparin-free anticoagulant infection inhibitor for hemodialysis and a preparation method thereof. The heparin-free anticoagulant infection inhibitor is a preparation comprising the following components in parts by weight: 1 part of sodium citrate, 0.001-0.8 part of methylene blue and 0.001-10.0 parts of chondroitin sulfate as well as a proper amount of adjuvant and an excipient optionally. The heparin-free anticoagulant infection inhibitor has synergetic advantages compared with heparin and other species of single-component dialysis anticoagulants, has no toxic or adverse effect contraindications of heparin, is suitable for more target users than heparin, and provides biological protection for dialysis infection (bacterial or viral infection) which easily occurs in medical care personnel and patients and reduces hemodialysis infection of operators and patients. The heparin-free anticoagulant infection inhibitor has the advantages of easily-accessible raw materials, low price, large market and stable supply, and has good application prospects and social and economic benefits.

Description

1. Technical field: [0001] The invention belongs to the field of medical materials. 2. Technical background: [0002] (1) Present status of hemodialysis: Hemodialysis (HD), hemofiltration (HF) and hemodiafiltration (HDF) are currently the three most commonly used treatments for patients with chronic renal insufficiency, failure and liver cirrhosis. It is an irreplaceable hemodialysis measure to remove toxins (such as urea, creatinine, uric acid, etc.) and excess water from the patient's body to keep the internal environment of such patients relatively stable. There are a large number of patients who need hemodialysis treatment. These patients are highly dependent on hemodialysis and need to continue dialysis once or more times a week during their survival to support their lives. [0003] The dialysis process requires anticoagulation measures to ensure the smooth completion of dialysis. Due to the high price of heparin, it is an important factor in the cost of dialysis. The ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/194A61K31/5415A61K31/737A61P7/02A61P13/04A61P39/02A61P31/04A61P31/10A61P31/12
Inventor 王啸龙潘玲王民
Owner 王啸龙
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