Method for preparing uniform polymer beads
A polymer particle, uniform technology, applied in peptide preparation methods, biochemical equipment and methods, chemical instruments and methods, etc., can solve problems such as poor stabilizer, suspension failure, bead fusion, etc.
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Embodiment 1
[0061] Example 1 : Preparation of 58 micron GMA / GlyDMA porous particles in a 20 liter reactor
[0062] Into a 10-liter stainless steel vessel equipped with an overhead stirrer was added 3,213 grams of deionized water. The reactor was heated to 80° C., and 32.5 grams of Gohsenol GR-14R PVOH produced by Nippon GOHSEI, Japan, were slowly added within 30 minutes. The PVOH solution was stirred at a temperature of 80°C for 1 hour and then cooled to 30°C.
[0063] In another 30-liter vessel, 9,707 grams of deionized water was added, and the vessel was heated to 55° C. with stirring at 100 rpm. Slowly add 48.8 grams of Methocel, manufactured by The Dow Chemical Company, Philadelphia, PA, to the container over a period of 1 minute. TM K100, heat to 80°C and keep for 15 minutes. The vessel was cooled to 25°C.
[0064] In another 10-liter container, add 2,019 grams of the prepared PVOH solution, 924.6 grams of GMA, 616.4 grams of GlyDMA, 2,457.7 grams of DEP, 753.3 grams of MIBC a...
Embodiment 2
[0066] Example 2 Preparation of 60 µm GMA / GlyDMA Porous Particles
[0067] Add 321 grams of deionized water to a 600 mL beaker equipped with a magnetic stirrer. The beaker was heated to 80°C and 3.25 grams of Gohsenol GR-14R PVOH was slowly added over a period of 10 minutes. The PVOH solution was stirred at a temperature of 80°C for 1 hour and then cooled to 30°C.
[0068] In another beaker, add 970 grams of deionized water, then heat the beaker to 80°C and stir with a magnetic stirrer. To this beaker was slowly added 4.88 grams of Methocel K100 over a period of 10 minutes. The Methocel was stirred at a temperature of 80°C for 1 hour and then cooled to 25°C.
[0069] 201.9 grams of the prepared PVOH solution, 92.46 grams of GMA, 61.64 grams of EGDMA, 245.7 grams of DEP, 753.3 grams of MIBC (4-methyl-2-pentanol) and 2.13 grams of tert-butyl peroctoate were added to a 1-liter beaker. The mixture was stirred at 400 rpm for 10 minutes.
[0070] In a 2-liter glass reactor e...
Embodiment 3
[0071] Example 3 Preparation of 30 µm GMA / EDGMA Porous Particles
[0072] Add 300 g of deionized water to a 600 mL beaker equipped with a magnetic stirrer. The beaker was heated to 80°C and 3 grams of Gohsenol GR-14R PVOH was slowly added over a period of 10 minutes. The PVOH solution was stirred at a temperature of 80°C for 1 hour and then cooled to 30°C.
[0073] In another beaker, 75 grams of deionized water was added, then the beaker was heated to 80°C and stirred using a magnetic stirrer. To this beaker was slowly added 6.25 grams of Methocel K100 over a period of 10 minutes. The Methocel was stirred at a temperature of 80°C for 1 hour and then cooled to 25°C.
[0074] 228.2 g of the prepared PVOH solution, 74.1 g of GMA, 49.4 g of EGDMA, 229.5 g of DEP and 1.8 g of tert-butyl peroctoate were added to a 1-liter beaker, and the mixture was stirred at 400 rpm for 10 minutes.
[0075] In a 1 liter glass reactor equipped with an overhead stirrer and condenser, 198.0 gr...
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