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Alkaline solvent for dissolving high-molecular-weight chitosan and using method thereof

An alkaline solvent, high molecular weight technology, applied in the field of solvents for dissolving high molecular weight chitosan, can solve the problems of reduced molecular weight of chitosan, polydispersity, and no alkaline solvent that can dissolve high molecular weight chitosan, etc. To achieve the effect of being simple to use and avoiding a substantial decrease in strength

Inactive Publication Date: 2011-08-03
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used solvents at home and abroad are various dilute acids, and chitosan is extremely unstable in acidic solutions, which will cause partial hydrolysis of chitosan long chains and cleavage of glycosidic bonds, resulting in reduced molecular weight and polydispersity of chitosan. , resulting in insufficient performance of chitosan products
Chinese patent CN101215341A discloses an alkaline solvent capable of dissolving middle and low molecular weight chitosan, but so far there is no alkaline solvent capable of dissolving high molecular weight chitosan

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Mix 15.0 grams of lithium hydroxide, 12.5 grams of sodium hydroxide and 40.0 grams of urea, then add 430.0 grams of water and 2.5 grams of glycerol to form a transparent alkaline solvent under magnetic stirring.

[0018] Disperse 5.0 grams of chitosan powder with a deacetylation degree of 60% and a molecular weight of 3 million in the above-mentioned alkaline solvent, let it stand for 3 hours to fully swell, then freeze the swelling solution at -60°C, and thaw at 10°C before use , Dissolve it completely under mechanical stirring to obtain a transparent high molecular weight chitosan solution. Gained solution is vacuum-filtered with 2# sand core funnel, and solution can be filtered completely, and gained solution is clear and transparent, shows that high molecular weight chitosan can dissolve completely in the alkaline solvent that this example makes. The solution was placed for 6 weeks, and the viscosity remained basically unchanged, indicating that the chitosan alkalin...

Embodiment 2

[0020] Mix 17.5 grams of lithium hydroxide and 15.0 grams of sodium hydroxide into 440.0 grams of water, then add 22.5 grams of urea and 5.0 grams of glycerol to form a transparent alkaline solvent under magnetic stirring.

[0021] Disperse 7.5 grams of chitosan powder with a deacetylation degree of 69% and a molecular weight of 5 million in the above-mentioned alkaline solvent, let it stand for 2 hours to fully swell, then freeze the swelling solution at -40°C, and thaw at 0°C before use , Dissolve it completely under mechanical stirring to obtain a transparent high molecular weight chitosan solution. Gained solution is vacuum-filtered with 2# sand core funnel, and solution can be filtered completely, and gained solution is clear and transparent, shows that high molecular weight chitosan can dissolve completely in the alkaline solvent that this example makes. The solution was placed for 6 weeks, and the viscosity remained basically unchanged, indicating that the chitosan alka...

Embodiment 3

[0023] Mix 15.0 grams of lithium hydroxide and 15.0 grams of sodium hydroxide into 420.0 grams of water, then add 40.0 grams of urea and 10.0 grams of glycerol to form a transparent alkaline solvent under magnetic stirring.

[0024] Disperse 10.0 grams of chitosan powder with a deacetylation degree of 78% and a molecular weight of 4 million in the above-mentioned alkaline solvent, let it stand for 1 hour to fully swell, then freeze the swelling solution at -50°C, and thaw at 40°C before use , Dissolve it completely under mechanical stirring, and then obtain a transparent high molecular weight chitosan solution. Gained solution is vacuum-filtered with 2# sand core funnel, and solution can be filtered completely, and gained solution is clear and transparent, shows that high molecular weight chitosan can dissolve completely in the alkaline solvent that this example makes. The solution was placed for 6 weeks, and the viscosity remained basically unchanged, indicating that the chit...

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PUM

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Abstract

The invention discloses an alkaline solvent for dissolving high-molecular-weight chitosan, which can be used for dissolving chitosan with the molecular weight of between 1 million and 6 million. The alkaline solvent comprises the following components in percentage by weight: 1.0-5.0 percent of lithium hydroxide, 0-4.0 percent of sodium hydroxide, 4.0-9.0 percent of urea, 0.1-3.0 percent of glycerin and the balance of water. By adopting the solvent disclosed by the invention, the problem of great reduction in the intensity of a product caused by degradation of the high-molecular-weight chitosan in an acid solvent can be solved. A using method of the solvent disclosed by the invention is simple. A solution in which the high-molecular-weight chitosan is dissolved can be used for researching the relation between the dissolution behavior and the molecular structure of the high-molecular-weight chitosan, and can be applied to processing of products such as high-intensity chitosan gel, chitosan fibers, chitosan bar materials, chitosan bracket materials and the like.

Description

technical field [0001] The invention relates to a solvent for dissolving high molecular weight chitosan, especially an alkaline solvent for dissolving high molecular weight chitosan and its usage. Background technique [0002] Chitosan has good biocompatibility and biodegradability, and can be used in fields such as medical care and tissue engineering. However, high molecular weight chitosan products (such as dialysis membranes, fibers, scaffolds or gels) have the advantages of high strength and good performance. With the expansion of the application range, the demand for high molecular weight chitosan will inevitably increase. At present, the commonly used solvents at home and abroad are various dilute acids, and chitosan is extremely unstable in acidic solutions, which will cause partial hydrolysis of chitosan long chains and cleavage of glycosidic bonds, resulting in reduced molecular weight and polydispersity of chitosan. , resulting in insufficient performance of chito...

Claims

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Application Information

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IPC IPC(8): C08J3/05C08L5/08
Inventor 胡巧玲李友良张雨菲艾锋邓海琴张珂
Owner ZHEJIANG UNIV
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