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Methylphenidate patch

A methylphenidate and patch technology, applied in the field of methylphenidate patches, can solve the problems of slow release rate and other issues, and achieve the effects of reduced impulsive behavior, superior skin permeability, and superior drug availability

Inactive Publication Date: 2011-08-24
阿夫瓦药物输送系统公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In general, the rate of drug release from patches is slow compared to the rate of release from formulations for oral administration such as tablets, capsules, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] The first polyisobutylene (viscosity average molecular weight: 4,000,000, 20 parts), the second polyisobutylene (viscosity average molecular weight: 55,000, 20 parts), and polybutene (kinematic viscosity: 4000 mm 2 / s (100°C), 60 parts) were mixed to obtain the adhesive composition A containing polyisobutylene.

Embodiment 2

[0090] Solution polymerization of 2-ethylhexyl acrylate (71 parts), vinyl acetate (22 parts) and 2-hydroxyethyl acrylate (7 parts) in ethyl acetate at 60°C under an inert gas atmosphere Acrylic copolymer adhesive composition B was obtained.

Embodiment 3

[0092] Under an inert gas atmosphere, 2-ethylhexyl acrylate (95 parts) and acrylic acid (5 parts) were solution polymerized in ethyl acetate at 60° C. to obtain an acrylic copolymer adhesive composition C.

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PUM

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Abstract

The invention provides a methylphenidate patch which has superior stability of traditional Chinese medicines (methylphenidate and / or salt thereof) of the patch, superior skin permeability of traditional Chinese medicines in the patch using process and superior methylphenidate availability. The patch comprises a support body and an adhesive layer formed on at least one surface of the support body, wherein the adhesive layer contains methylphenidate and / or salt thereof, polyisobutylene and liquid plasticizer. Preferably, the HLB (hydrophile-lipophile balance) value of the liquid plasticizer is 1.0-3.3.

Description

technical field [0001] The present invention relates to a methylphenidate patch (a patch comprising methylphenidate and / or a salt thereof as a drug). More specifically, the present invention relates to a methylphenidate patch superior in the stability of the drug in the patch, the skin permeability of the drug during patch use, and the availability of the drug. Background technique [0002] Attention deficit disorder and ADHD are the most common in children with mental disorders. The reported incidence of attention deficit disorder ranges from 4% to 9%. [0003] Attention deficit disorder and ADHD are characterized by carelessness and impulsivity, often with hyperactivity. Their occurrence may be associated with emotional disturbances that may cause aggression, stealing, lying, truancy, arson, flight, tantrums, etc., or sometimes with diminished or diminished cognitive and learning abilities and social skills. [0004] Methylphenidate is a psychostimulant most commonly us...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/4458A61K47/32A61P25/14A61P25/00
Inventor 原巧田村圭井之阪敬悟佐伯有史
Owner 阿夫瓦药物输送系统公司
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