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Antimicrobial gel formulations

A preparation and derivative technology, applied in the field of stable antimicrobial preparations, can solve the problems of unstable compounds, difficult compound preparation, etc., and achieve the effect of increasing effectiveness

Inactive Publication Date: 2011-09-07
NOVABAY PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the reactivity of these compounds, it is difficult to formulate this compound for various applications
[0005] Although such compounds need to be formulated in polymers (such as gels) to have properties such as adhesion to the skin or mucous membranes, and to remain on such tissues for a sufficient some compounds are unstable in the polymer and will react with or degrade in the polymer

Method used

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Examples

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Embodiment 1

[0272] Example 1: AA-1 Gel Formulation

[0273] A formulation of 1% N,N-dichloro-2,2-dimethyltaurine in 1% AA-1 was prepared by the following method. Prepared by slowly adding the gelling agent to the water while stirring to prevent the gelling agent from clumping 1.5% (w / v) solution of AA-1 polycarbophil. A 4% (w / v) solution of N,N-dichloro-2,2-dimethyltaurine was prepared separately. The above two solutions were mixed to form a 1% N,N-dichloro-2,2-dimethyltaurine / 1% AA-1 solution. The pH of the solution was adjusted to about 5.0 with HCl (NaOH if necessary).

Embodiment 2

[0274] Embodiment 2: Eucalyptol preparation

[0275] A solution of 1% N,N-dichloro-2,2-dimethyltaurine ("NVC-422") in 0.2% cineole was prepared by mixing 1% (w / v) NVC-422 with 100ml 0.9% salt (NaCl) solution was mixed, and then 0.2% 1,8-cineole (v / v) was added. The resulting solution was clear and colorless, and had a pungent, eucalyptus-like odor.

Embodiment 3

[0276] Embodiment 3: 3-octanone preparation

[0277] A 1% NVC-422 solution in 0.5% 3-octanone was prepared by mixing 1% NVC-422 (w / v) with 100 ml of a 0.9% salt (NaCl) solution and then adding 0.5% 3-octyl Ketones (v / v). The resulting solution was clear and colorless and had a strong, sweet, floral odour.

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Abstract

Disclosed herein are formulations comprising an N-halogenated or N,N- dihalogenated amine compound dispersed in a water-swellable polymer, wherein the compound is 90% stable for at least 30 days at about 250C. Also disclosed are methods of treating or preventing infections caused by a bacterial, a microbial, a sporal, a fungal or a viral activity using such formulations.

Description

[0001] related application [0002] This application claims priority to US Provisional Application No. 61 / 088,302, filed August 12, 2008, and US Provisional Application No. 61 / 229,624, filed July 29, 2009. The entire contents of US Application Nos. 61 / 088,302 and 61 / 229,624 are incorporated herein by reference. technical field [0003] The present invention relates to stable antimicrobial formulations of one or more N-halo or N,N-dihaloamine compounds dispersed in one or more water-swellable polymers (or water-swellable polymers). Background technique [0004] Certain chlorinated amine compounds, such as chlorinated taurine derivatives, have high antimicrobial activity and low cytotoxicity, and have been shown to be effective against bacteria, viruses, fungi, and other infectious pathogens. See, eg, US Patent No. 7,462,361 (M. Bassiri et al.). However, due to the reactivity of these compounds, it is difficult to formulate this compound for various applications. [0005] A...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K9/00
CPCA61Q17/005A61K8/466A61K31/125A61K8/042A61Q19/10A01N59/00A61K9/0014A61K9/06A61K31/352A01N41/08A61K8/8147A61Q5/02A61K8/55A61Q11/00A61K47/22A61K8/416A61K8/44A61K8/86A61P17/10A61P31/00A61P31/02A61P31/04A61P31/10A61P31/12A01N25/04A01N25/10A61K31/155A61K31/145A61K31/185
Inventor 王露阿扎尔·纳杰菲巴拉姆·梅马扎德库尔迪帕克·夏尔马金·弗昂·霍
Owner NOVABAY PHARM INC
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