Application of cobra venom neurotoxin in drugs for treating ametropia

A cobra venom and refractive error technology, applied in the field of biomedicine, can solve problems such as unseen research and application reports, and achieve the effect of treating refractive errors

Inactive Publication Date: 2011-09-14
KUNMING MAOBO BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The applicant has searched relevant patents and scientific periodical databases, and there is no report on the research and application of snake venom neurotoxin or its analogues for the treatment of refractive errors

Method used

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  • Application of cobra venom neurotoxin in drugs for treating ametropia
  • Application of cobra venom neurotoxin in drugs for treating ametropia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]Example 1: Cobra venom was purified by ion exchange column chromatography to obtain cobra venom neurotoxin, which was prepared into eye drops with a content of 30-120 ug / ml with physiological saline.

Embodiment 2

[0028] Example 2: The venom neurotoxin was obtained by purifying king cobra venom through gel filtration chromatography and ion exchange chromatography, and preparing eye drops of 70 ug / ml with physiological saline.

Embodiment 3

[0029] Example 3: Cobra venom was purified by ion-exchange column chromatography to obtain cobra venom neurotoxin, and eye drops with a content of 50 ug / ml were formulated with normal saline added with conventional amounts of vitamin E and taurine.

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PUM

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Abstract

The invention relates to application of cobra venom neurotoxin in pharmacy, particularly in drugs for treating ametropia, belonging to technical field of biomedicine. The invention particularly relates to application of cobra venom neurotoxin or a hydrolyzed fragment of the neurotoxin. The neurotoxin or the hydrolyzed fragment of the neurotoxin can be an active ingredient used for preparing drugs for treating ametropia only or together with antibiotics. According to the invention, as an active ingredient for treating ametropia, the cobra venom neurotoxin with low dosage not only can stop signal transduction of neuromuscular junctions, but also can adjust a receptor of the cobra venom neurotoxin to balance a nerve-muscle function, thereby achieving the aim of treating ametropia.

Description

technical field [0001] The invention relates to a new application of cobra venom neurotoxin in pharmacy, especially the application in medicine for treating ametropia, and belongs to the technical field of biomedicine. Background technique [0002] At present, myopia has become an important issue affecting the health of our people. In 2004, the Ministry of Education made a "2004 National Student Physical Health Monitoring Report". In this report, the detection rate of poor vision in primary school students aged 7 to 12 in my country is 32.5%, that of junior high school students is 59.4%, that of high school students is 77.3%, and that of college students is 80.0%. %, the incidence of poor vision among students is increasing year by year. And the myopia high-incidence group——juvenile myopia incidence is as high as 50% to 60%. my country is one of the countries with the highest incidence of myopia in the world, and the number of myopia is the first in the world. In recent ye...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K38/01A61K35/58A61P27/02A61K35/583
Inventor 钟树荣
Owner KUNMING MAOBO BIOLOGICAL TECH
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