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Anti-acne snake venom compound external application preparation and preparation method thereof

A technology of topical agent and snake venom, which is applied in the field of anti-acne snake venom compound topical agent and its preparation, which can solve the problems of skin penetration, absorption stability, low targeting, skin irritation and drug resistance, and insufficient clinical curative effect Ideal and other issues, to achieve the effect of reducing skin irritation and drug resistance, reducing sebum secretion, and avoiding skin adverse reactions

Inactive Publication Date: 2016-11-09
GUANGZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These anti-acne drugs all have unsatisfactory clinical efficacy, and have adverse reactions such as dry skin, desquamation, erythema, itching and other skin irritation and drug resistance; pharmaceutical preparations also have transdermal, absorbability, stability and targeting not high problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0020] Dissolve 1g of cobra snake venom in 100ml of deionized water, centrifuge at 4°C and 5000rpm for 15 minutes, and take the supernatant for gel filtration chromatography; gel filtration uses Sephadex-G-75 gel column with a column height of 100cm and an inner diameter of 1.6cm , the eluent is the ammonium acetate solution of 0.05mol / L, the elution rate is 16ml / h, and 1 tube is collected in 10 minutes; the toxin components that cause hemorrhage are removed after separation, and the remaining components are freeze-dried to obtain the refined cobra venom dry powder.

[0021] Baicalein is extracted from Scutellaria baicalensis Chinese medicinal materials, the specific implementation method:

[0022] Add 100g of medicinal material Scutellaria baicalensis, add 500ml of distilled water after crushing, pass through a 20-mesh sieve after fully stirring, add 2000U cellulase at 40°C, pH4.5 for enzymolysis for 24 hours, then suction filter, add 60% ethanol to the solid obtained by suct...

Embodiment 1

[0024] Embodiment 1, containing cobra family snake venom dry powder 70g, baicalein product 30g in every 100g mixture;

Embodiment 2

[0025] Embodiment 2, containing cobra family snake venom dry powder 65g, baicalein product 35g in every 100g mixture;

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PUM

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Abstract

The invention discloses an anti-acne snake venom compound external application preparation and a preparation method thereof. The anti-acne snake venom compound external application preparation contains 1 to 8 percent of active pharmaceutical ingredients, wherein the active pharmaceutical ingredients are obtained by mixing 50 to 70 percent of dry elapidae snake venom powder with 30 to 50 percent of baicalein product, the percentage is by mass. Per 100g of fined dry elapidae snake venom powder is prepared from the following components: 6 to 12g of neurotoxin, 10 to 45g of cardiotoxin, 1.5 to 3g of cobra venom factor and 0.2 to 0.5g of cobra venom nerve growth factor; the content of baicalein in per 100g of the baicalein product is greater than 98g. The neurotoxi, cytotoxin and nerve growth factor of cobra venom have the effects of inhibiting bacteria, resisting inflammation, resisting allergy and relieving skin lesion; by coordinating the effects of the cobra venom with the effects of resisting oxidation, resisting inflammation and reducing grease secretion of the baicalein, the skin irritation and drug resistance of an anti-acne medicament can be reduced, and a more ideal biological agent is provided for clinical acne treatment.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular to an anti-acne snake venom compound external preparation and a preparation method thereof. Background technique [0002] Acne is a common skin disease caused by chronic inflammation of hair follicles and sebaceous glands. It mainly occurs on the face and forms skin lesions such as comedones, papules and pustules. Some types of acne can cause hyperpigmentation and permanent scarring, which can have a detrimental effect on the patient's appearance and psychology. Epidemiological surveys show that 90% of adolescents have acne of varying severity, among which the incidence rates of adolescent boys and girls are 95% and 83%, respectively, and the incidence rate among adults aged 25-34 is as high as 80%. [0003] Topical administration is the first choice for clinical treatment of mild acne, and it is also the basic drug for moderate and severe acne. At present, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/583A61K31/352A61P17/10
CPCA61K9/0014A61K31/352A61K35/583A61K2300/00
Inventor 张梅余细勇朱柳周毅
Owner GUANGZHOU MEDICAL UNIV
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