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Novel anti-depression compound preparation

A compound preparation and anti-depressant technology, which is applied in pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of long clinical treatment cycle, out-of-sync target effects, side effects, etc.

Inactive Publication Date: 2011-09-21
UNIV OF ELECTRONICS SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional antidepressant drugs are designed based on the monoamine system. Although there are many kinds of drugs with different mechanisms of action, they generally have defects such as long clinical treatment cycle, asynchronous target effect and symptom improvement, and serious side effects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 The antidepressant effect of novel antidepressant compound preparation in mice forced swimming test

[0023] experimental method:

[0024] The forced swimming test was first established by Porsolt. Its basic principle is that when a mouse swims in a narrow and unavoidable container, after the initial struggle, the body will float in the water or slide back slightly to maintain a Immobility behavior, also known as hopelessness behavior, was reduced when the animals received antidepressant drugs before the experiment.

[0025] In the experiment, 35 mice were divided into five experimental groups of normal saline, low (225mg / kg), medium (450mg / kg), high-dose (900mg / kg) drugs and imipramine (30mg / kg). Group 7 animals. The drugs were orally fed 24 hours, 1 hour and 30 minutes before the experiment, and then the mice were placed in a glass cup with a water depth of 12 cm, a water temperature of 22±1°C, and a size of 21×12 cm. Swimming was maintained for 6 minutes...

Embodiment 2

[0031] Antidepressant effect of embodiment 2 novel antidepressant compound preparation in mouse tail suspension experiment

[0032] experimental method:

[0033] The tail-suspension test is a rapid, high-throughput screening method for the acute behavioral effects of antidepressants. The main basis is that when a normal animal is in a short-term unavoidable adversity (such as hanging its tail at a certain height from the ground), its behavior will switch from a moving state to an immobile state, and giving antidepressant drugs before the experiment will not The time of immobility in this can be reduced.

[0034] In the experiment, 35 mice were divided into five experimental groups of normal saline, low (225mg / kg), medium (450mg / kg), high-dose (900mg / kg) drugs and imipramine (30mg / kg). Group 7 animals. The drugs were orally fed 24 hours, 1 hour and 30 minutes before the experiment, and then the tail tip of the mouse was fixed at a height of 60 cm from the ground and suspende...

Embodiment 3

[0040] Example 3 The impact of novel antidepressant compound preparation compound on spontaneous activity measurement in mice

[0041] experimental method:

[0042]The test of mouse spontaneous activity was tested by Taimeng ZZ-6 mouse autonomous activity tester. In the experiment, 35 mice were divided into low (225mg / kg), medium (450mg / kg) and high dose (900mg) saline / kg) drug and imipramine (30mg / kg) five experimental groups, 7 animals in each group. The drugs were orally fed 24 hours, 1 hour and 30 minutes before the experiment respectively, and the mice were placed in the measuring chamber of the tester, allowed to adapt for 5 minutes, and then recorded the number of activities and the number of standing of the mice within 20 minutes.

[0043] Experimental results:

[0044] The effects of different doses of drugs, imipramine, and normal saline on the spontaneous activities of mice are represented by the number of spontaneous activities (Table 3) and the number of standi...

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Abstract

The invention relates to a formula of a novel anti-depression compound preparation and a preparation method. The novel anti-depression compound preparation consisting of ginsenoside, valerian and Omega-3 (or fish oil) together is designed, and a proportion and a preparation mode of the compound preparation are determined. Proved in experiments, the compound preparation has anti-depression effect, has the characteristics of safety, reliability and low cost, and can be prepared into various acceptable formulations for treating and preventing depression.

Description

technical field [0001] The invention relates to a new formula and preparation method of antidepressant compound preparation, more specifically, relates to a formula and preparation method of compound medicine preparation with antidepressant effect, and belongs to the field of natural medicine development. Background technique [0002] Affective disorder is a medical term describing abnormal mood, which is short-term depression in the face of some regrets or some disappointment. It is a common phenomenon in daily life, and when the symptoms persist When there is a serious, severe emotional disorder, it is called depression. Depression is a very common disease. About 10% of the population will suffer from different degrees of depression during certain periods of their lives, and patients with depression often have serious suicidal tendencies. According to surveys, more than 30,000 people in the United States commit suicide every year. Depression is thought to be a major facto...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P25/24A61K35/60
Inventor 鄢硕游自立丰毅谢雷
Owner UNIV OF ELECTRONICS SCI & TECH OF CHINA
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