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Synergetic method for bacterial inhibition of ceftriaxone sodium by chitosan

A technology of ceftriaxone sodium and ceftriaxone sodium, which is applied in the field of biomedicine, can solve the problems of uncontrollable dosage, unclear biological toxicity, and high cost, and achieve the effect of reducing clinical diagnosis procedures, reducing burden and pain, and simple equipment

Inactive Publication Date: 2011-09-28
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, nanomaterials, heavy metal materials, and other drugs have disadvantages such as high cost, uncontrollable dosage, and unclear biological toxicity. In the process of using drugs, adding non-biologically toxic natural materials can change the absorption, transportation, and mode of action of drugs , achieving better antibacterial effect with lower drug concentration has become a valuable research direction

Method used

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  • Synergetic method for bacterial inhibition of ceftriaxone sodium by chitosan
  • Synergetic method for bacterial inhibition of ceftriaxone sodium by chitosan
  • Synergetic method for bacterial inhibition of ceftriaxone sodium by chitosan

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Effect test

Embodiment 1

[0031] (1) Preparation of chitosan acetic acid solution: Weigh 0.01 g chitosan and dissolve it in 10 ml 2% acetic acid solution, heat and stir until fully dissolved, and present a colorless and transparent viscous solution with a concentration of 1 mg / ml. Add commercially available ceftriaxone sodium for injection (1 g) into 10 ml of sterile water to prepare a 100 mg / ml medicinal solution for use.

[0032] (2) Under the condition of ultrasonic stirring, the chitosan acetic acid solution is mixed with the commercially available ceftriaxone sodium solution for injection according to the mass ratio of 1: 0.5, and stirred for 30min so that the two are fully mixed to reach the bacteriostatic performance of ceftriaxone sodium Perform chitosan synergy.

[0033] (3) Escherichia coli (BH21) must be activated in the frozen state to restore its activity. Add E. coli strains to LB liquid medium with an inoculum of 1%, and culture overnight at a temperature of 37.5°C in a constant temperat...

Embodiment 2

[0039] Under the condition of ultrasonic stirring, the chitosan acetic acid solution was mixed with the commercially available ceftriaxone sodium solution for injection according to the mass ratio of 1:2, and stirred for 30 minutes to fully mix the two to achieve chitosanization of the antibacterial properties of ceftriaxone sodium. Sugar synergy. As can be seen from the changes in the diameter of the inhibition zone in Table 1, it can be seen that the synergistic antibacterial performance is also better, exceeding the effect of the two alone.

Embodiment 3

[0041] Under the condition of ultrasonic stirring, the chitosan acetic acid solution was mixed with the commercially available ceftriaxone sodium solution for injection according to the mass ratio of 1:10, and stirred for 30 minutes to fully mix the two to achieve chitosanization of the antibacterial properties of ceftriaxone sodium. Sugar synergy. As can be seen from the changes in the diameter of the inhibition zone in Table 1, it can be seen that the synergistic antibacterial performance is also better, exceeding the effect of the two alone.

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Abstract

The invention relates to a synergetic method for bacterial inhibition of ceftriaxone sodium by chitosan. According to the method, a natural nontoxic macromolecular substance chitosan is added to the commercial ceftriaxone sodium to play a synergetic effect on the bacterial inhibition of the ceftriaxone sodium. Compared with the prior art, excellent synergetic bacterial inhibition of the ceftriaxone sodium is achieved by the chitosan, thus greatly reducing the dosage of the original ceftriaxone sodium, and achieving a better bacterial inhibition effect by a lower drug concentration.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a synergistic synergistic method for chitosan on the antibacterial performance of ceftriaxone sodium. Background technique [0002] With the increasing use of antibiotics, bacteria show varying degrees of drug resistance to some commonly used drugs. For those drugs that are used for a longer period of time and are used more widely, the drug resistance of bacteria tends to be more serious. Ceftriaxone sodium also faces the same problem as the third-generation cephalosporin antibiotics. The usual solution is to use β-lactamase inhibitors to make a compound preparation of β-lactam antibiotics or increase the concentration of antibiotics. dosage, but the problem is that no matter what organic ingredients are added or the dosage of the drug is increased, the side effects of the drug on the human body will also increase. At the same time, it will cause that the course of treatm...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61P31/04A61K31/546
Inventor 张孟吴庆生
Owner TONGJI UNIV
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