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Method for purifying lysine
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A purification method and technology for lysine, applied in the field of lysine purification, can solve the problems of unfavorable process continuous operation, low lysine purity, decreased exchange and adsorption capacity of cation exchange resin, etc.
Active Publication Date: 2014-02-26
COFCO BIOTECHNOLOGY CO LTD
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[0005] After adopting the method for separating and purifying lysine of the prior art to purify and separate the solution containing lysine for a period of time, the exchange adsorption capacity of the cation exchange resin will significantly decrease, thereby greatly affecting the efficiency of the separation and purification of lysine. And it is unfavorable for the continuous operation of technology, moreover, the purity of the lysine product that obtains is lower
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Embodiment 1
[0069] This example is used to illustrate the purification method of lysine.
[0070] (1) will be 0.8m 3 Lysine fermentation liquid (lysine content 11.2g / 100ml, purity 59.4% by weight) carries out membrane filtration (membrane material is pottery (membrane surface microporous UF1 aperture 0.1um, UF2 aperture 0.2um), membrane filtration pressure is 1.5bar , membrane filtration temperature is 75 DEG C, and filtration time is 1 hour), obtains the lysine fermented supernatant liquid that the pH value is 3 through membrane filtration, and mixes with washing liquid (the washing liquid that step (3) obtains), and washing liquid The consumption that makes the pH value of the mixed solution containing lysine obtained is 6;
[0071] (2) at 40 DEG C, the solution containing lysine with a pH value of 6 obtained in step (1) is continuously pumped in from the upper end of the resin column group at the first place in the adsorption area (the flow rate of the solution containing lysine is 6...
Embodiment 2
[0078] This example is used to illustrate the purification method of lysine.
[0079] Purify lysine according to the method of Example 1, except that in step (1), the amount of washing liquid is such that the pH value of the resulting mixed solution containing lysine is 3.5. In the obtained lysine eluate, the content of lysine was 21.4 g / 100 ml, and the purity was 96% by weight.
Embodiment 3
[0081] This example is used to illustrate the purification method of lysine.
[0082] According to the method for embodiment 1, lysine is purified, and difference is:
[0083] In step (1), the amount of washing liquid makes the resulting mixed solution containing lysine have a pH value of 3.5;
[0084] In step (2), the temperature of ion exchange is 50°C, the flow rate of the solution containing lysine is 5m / h, and the weight ratio of the solution containing lysine to the resin is 1.6:1;
[0085] In step (3), the temperature of the eluent is 60° C., the flow rate of the eluent is 9.5 m / h, and the weight ratio of the eluent to the resin adsorbed with lysine is 1:1;
[0086] In step (4), the analytical temperature is 60° C., and the adsorbed resin column of step (3) is eluted successively with 5.6% by weight of dilute ammonia water, and the flow rate of ammonia water is 13.6 m / h. The weight ratio of the resin of amino acid is 0.9: 1, and the lysine eluate (purity 96.5% by weig...
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Abstract
The invention provides a method for purifying lysine, comprising the following steps of: (1) contacting a lysine-containing solution with a cation exchange resin for carrying out ion exchange to ensure that the lysine is adsorbed onto the cation exchange resin, wherein the pH value of the lysine-containing solution is 3.5-6; (2) eluting the cation exchange resin adsorbed with the lysine in the step (1) with an eluent to ensure that the lysine-containing solution adsorbed onto the cation exchange resin by the eluent is replaced so as to obtain a cleaning solution; (3) eluting the lysine adsorbed onto the cation exchange resin in the step (2) with ammonia water to obtain a lysine eluent; and (4) regenerating resin by contacting the cation exchange resin eluted with the ammonia water in the step (3) with a sulphuric acid solution, and reusing the regenerated cation exchange resin in the step (1). According to the method provided by the invention, the exchange adsorption capacity of the lysine and the cation exchange resin can be greatly improved.
Description
technical field [0001] The invention relates to a method for purifying lysine. Background technique [0002] Lysine is one of more than 20 kinds of amino acids. It is indispensable for humans and animals and is one of the eight essential amino acids that cannot be synthesized by humans. It is the main component of protein. The continuous improvement of people's quality of life and the change of food structure have accelerated the increase in the total consumption demand of lysine, and now it has become an important raw material for food, medicine, feed industry and cosmetics and other industries. [0003] In 2000, the production capacity of lysine in the world was 600,000 tons, and the output reached 500,000 tons. In recent years, the total production capacity of lysine in the world has exceeded 2 million tons per year, and the international consumption of lysine has reached more than 1 million tons per year. China's annual production capacity of lysine increased from less...
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