Method for preparing 5'-cytidylic acid from composite solvent and bind acid agent
A composite solvent and acid-binding agent technology, applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve problems such as unstable product quality, achieve high selectivity and speed up the effect
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[0013] Embodiment 1: A method for making 5'-cytidylic acid using a composite solvent and an acid-binding agent, has the following steps:
[0014] (1) Prepare composite solvent: the composite solvent contains sulfoxide solvent and tri-lower alkyl phosphate, and the ratio of sulfoxide solvent to tri-lower alkyl phosphate is 50g:500g. During the reaction, a sulfoxide solvent and a tri-lower alkyl phosphate are used as a composite solvent, which utilizes the property that the composite solvent can increase the solubility or dissolution rate of the solute to ensure that there is no interference in the next reaction, that is, the reaction has a directional property, specifying the introduction of a phosphate group at the 5'-position of cytidine upon phosphorylation of cytidine.
[0015] (2) Adding phosphorylating agent: the phosphorylating agent is phosphorus oxyhalide, and phosphorus oxyhalide is phosphorus oxychloride or phosphorus oxybromide. The non-interfering reaction is carr...
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