Chinese medicinal composition for promoting nerve regeneration and preparation method and use thereof

A technology of nerve regeneration and composition, which is applied in the direction of drug combination, application, food preparation, etc., can solve the problems of wide application limitation and high manufacturing cost, and achieve the effect of wide application value, low dosage and stable quality

Active Publication Date: 2011-11-09
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although the formula has a good effect of resisting cerebral ischemic injury and improving learning and memory, because the formula is a pure chemical composition formula, the source of raw materials of each component is subject to certain restrictions, the manufacturin...

Method used

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  • Chinese medicinal composition for promoting nerve regeneration and preparation method and use thereof
  • Chinese medicinal composition for promoting nerve regeneration and preparation method and use thereof
  • Chinese medicinal composition for promoting nerve regeneration and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Preparation of total extract of traditional Chinese medicine compound (WSXN1)

[0048] Shouwu 100 kg, ginseng 90 kg, ginkgo leaves 60 kg.

[0049] Take the prescribed amount of ginseng, crush it into a coarse powder, and extract 10 times, 8 times and 6 times the amount of medicinal materials by refluxing 60% ethanol for 3 times, each time for 2 hours, combine the extracts, recover the ethanol under vacuum and decompression, and make it The concentration of alcohol extraction part is 1 ml is equivalent to 1 g crude drug.

[0050] The treatment method of Ginkgo biloba is the same as that of ginseng, and the concentration of the final alcohol extraction part is 1 ml, which is equivalent to 1 g of crude drug.

[0051] Shouwu was decocted and extracted 3 times with 10 times, 8 times and 6 times of the amount of medicinal materials, each time for 2 hours, combined 3 times of water extracts, and concentrated under vacuum to 1ml of the extract, which is equivalent to...

Embodiment 2

[0056] Example 2 Preparation of total extract of traditional Chinese medicine compound (WSXN1-2)

[0057] Shouwu 100 kg, ginseng 90 kg, ginkgo leaves 60 kg.

[0058] The above medicinal materials are crushed into coarse powder, boiled with 12 times, 10 times and 6 times the amount of medicinal materials in water for 2 h, 1.5 h and 1 h respectively, filtered, and the combined filtrates are concentrated to 1 ml under reduced pressure at 80 °C Equivalent to containing 1g crude drug, add 95% ethanol to make the alcohol content reach 70%, let it stand overnight, filter the ethanol solution to recover ethanol under vacuum and reduce pressure, concentrate to obtain 1g medicinal material / ml concentrated alcohol extract, and divide the total alcohol extract The concentrated solution is added to the treated macroporous adsorption resin (PD100 polystyrene weakly basic anion exchange resin), and the dosage ratio of the macroporous resin to the concentrated solution is 1kg of macroporous...

Embodiment 3

[0062] Example 3 Preparation of Shouwu, Ginseng, and Ginkgo Leaf Extracts

[0063] 1 Preparation of Shouwu Extract 1

[0064] Take 500 kg of Polygonum multiflorum and crush it into a coarse powder, and extract 3 times with 70% ethanol with 10 times, 8 times and 6 times the weight of the medicinal material under reflux, each time for 2 hours, combine the extracts, recover ethanol under vacuum and decompression and make the alcohol The concentration of the extracted part is 1 ml of total alcohol extract equivalent to 1 g of crude drug; the total alcohol extract is added to the treated macroporous adsorption resin (PD100 polystyrene weakly basic anion exchange resin), and the The dosage ratio of the alcohol extract is 1kg macroporous resin plus 2L of the total alcohol extract. Use 50%, 70%, 80% and 95% ethanol to elute sequentially, the dosage is 4 L, elute at a flow rate of 10 ml / min, collect the corresponding eluent, recover ethanol, dry; plaster, vacuum-dried, and pulveriz...

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Abstract

The invention discloses a Chinese medicinal composition for promoting nerve regeneration and a preparation method and use thereof. The Chinese medicinal composition for promoting nerve regeneration consists of 2 to 10 parts of multiflower knotweed root, 1 to 10 parts of ginseng and 1 to 10 parts of ginkgo leaves; and the Chinese medicinal composition for promoting nerve regeneration also may consist of commercial multiflower knotweed root extract, ginseng extract and ginkgo leaf extract in a ratio. Besides the conventional preparation method, the invention also provides a preparation method of the Chinese medicinal composition, which comprises: subjecting the raw materials to C1 to C1 alcohol extraction respectively to obtain C1 to C3 alcohol extracts; concentrating, passing through a macroporous adsorption resin column, eluting with ethanol, collecting eluent, recovering ethanol, and drying; or recovering ethanol, concentrating to obtain thick paste, drying, grinding, obtaining the final extracts, and mixing to obtain the Chinese medicinal composition. The Chinese medicinal compostion has an obvious nerve regeneration promoting effect, and has the effects of resisting cerebral ischemia injury, protecting nerves, improving learning and memory and resisting senile dementia; the main active ingredients are definite, the quality is stable, and the dosage is small; and the Chinesemedicinal composition is a high-quality natural medicine or health-care food.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for promoting nerve regeneration and its preparation method and application. Background technique [0002] Diseases related to cerebral ischemic injury include stroke, sequelae of stroke, and vascular dementia. Ischemic stroke is an important killer that threatens human health, and its incidence is very high in middle-aged and elderly people. It is estimated that there are nearly 5 million ischemic stroke patients in the country, and more than 20 million people worldwide, and the age of onset is getting younger and younger. Many ischemic stroke patients lose their ability to work, which seriously damages the social labor force and creativity. [0003] Alzheimer's disease is a common disease in the elderly, and there are different types such as vascular dementia (Vascular Dementia, VD) and senile dementia (Alzheime...

Claims

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Application Information

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IPC IPC(8): A61K36/704A23L1/29A61P9/10A61P25/28A23L33/00
CPCA61K36/16A23L1/29A61K36/258A61K36/704A61K36/70A61P9/10A61P25/28A61K2300/00
Inventor 贝伟剑郭姣
Owner GUANGDONG PHARMA UNIV
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