Compounds with thrombolytic activities and preparation methods and applications thereof

A compound, the technology of suppository activity, applied in the field of medicinal chemistry
CN102241740BInactive Publication Date: 2014-02-19CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Publication Date
2014-02-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses compounds with thrombolytic activities, preparation methods thereof and applications of the compounds as thrombolytic agents. The compounds disclosed by the invention are prepared by coupling or conjugating the 2 nitrogen of cyclized dopa respectively with H-Ala-Arg-Pro-Ala-Lys-OH, H-Pro-Ala-Lys-OH, H-Arg-Pro-Ala-Lys-OH, H-Gly-Arg-Pro-Ala-Lys-OH or H-Gln-Arg-Pro-Ala-Lys-OH. The thrombolytic activities of the compounds disclosed by the invention are evaluated by a rat model with carotid artery and jugular vein bypass catheter thrombosis, and shown by experimental results, the compounds disclosed by the invention have excellent thrombolytic activities and can be applied as thrombolytic agents clinically. The therapeutic actions of the compounds disclosed by the invention on cerebral infarction are further evaluated by a rat model with cerebral thrombosis, and shown by experimental results, the compounds disclosed by the invention all have excellent protective actions on brain tissues and can be applied as cerebral thrombolytic agents clinically.
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Description

[0001] This case is a divisional application with the application number "200810057220.2", the filing date is "January 30, 2008", and the invention title is "compound with thrombolytic activity, its preparation method, and its application". technical field

[0002] The present invention relates to a class of heterocyclic compounds, in particular to a compound with thrombolytic activity obtained by conjugating or coupling P6A or its analogs after dopa cyclization and a preparation method for the compound. This aspect also relates to The application of the compound as a thrombolytic agent, especially as a therapeutic agent for cerebral thrombosis, belongs to the field of medicinal chemistry. Background technique

[0003] Cerebral thrombosis is characterized by high morbidity, disability and death. Drug therapy is the main means of clinical treatment of cerebral thrombosis. The development of safe and effective drugs against cerebral thrombosis is one of the hot spots in the r...

Claims

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