Biocompatible fiber based device for guided tissue regeneration

A non-woven fiber, fiber technology used in tissue repair and regeneration to solve problems such as repairing implants, lack of strength and structural integrity

Inactive Publication Date: 2011-11-16
ADVANCED TECH & REGENERATIVE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While potentially useful, the implant material was deemed to lack sufficient strength and structural integrity to be a reliable tissue repair implant

Method used

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  • Biocompatible fiber based device for guided tissue regeneration
  • Biocompatible fiber based device for guided tissue regeneration
  • Biocompatible fiber based device for guided tissue regeneration

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0068] Example 1: By needle punching (GYNEMESH PS Mesh+90 / 10PGA / PLA nonwoven batting) to fabricate tissue engineering devices for pelvic floor repair

[0069] Prepared by Concordia Manufacturing, LLC (Coventry, RI) with a density of 2 mg / cm 2 90 / 10 (mol%) glycolide and lactide copolymer (90 / 10 PGA / PLA) fiber non-woven fiber mat. A 15 cm by 15 cm GYNEMESH PS mesh (Ethicon Inc, Somerville, NJ) was sandwiched between the nonwoven fibrous batts by placing a nonwoven batt on each side of the mesh. The construct is then passed through a needle loom to engage the fiber batt to embed the mesh within the nonwoven mat. Two acupuncture passes were performed to generate the device. GYNEMESH PS Mesh+90 / 10PGA / PLA nonwoven scaffold has a thickness of 1.17mm and a density of 75mg / cc.

[0070] Samples were analyzed by scanning electron microscopy (SEM). The samples were mounted on a microscope stand and a thin layer of gold was evaporated using an EMS 550 sputter coater (Electron Microsc...

example 2

[0071] Example 2: By needle punching (ULTRAPRO Mesh+90 / 10PGA / PLA nonwoven wadding Pads) to fabricate tissue engineered devices for pelvic floor repair

[0072] Prepared by Concordia Manufacturing, LLC (Coventry, RI) with a density of 2 mg / cm 2 90 / 10 PGA / PLA fiber non-woven fiber mat. A 15 cm x 15 cm ULTRAPRO mesh (Ethicon Inc, Somerville, NJ) was sandwiched between the nonwoven fibrous batts by placing a nonwoven batt on each side of the mesh. The construct is then passed through a needle loom to engage the fiber batt to embed the mesh within the nonwoven mat. Two acupuncture passes were performed to generate the device. Ultrapro mesh+90 / 10PGA / PLA non-woven scaffold has a thickness of 1.03mm and a density of 71mg / cc.

[0073] The tissue engineering device prepared according to the above steps was cut into a size of 4cm×4cm for rupture test. The burst strength of the device was evaluated using a Mullen burst test apparatus. The sample is placed in the grip area of ​​th...

example 3

[0075] Example 3: By needle punching (90 / 10 PGA / PLA fiber: PDO fiber ratio of 50:50 GYNEMESH PS mesh + non-woven fiber batt) to manufacture tissue engineering equipment for pelvic floor repair place

[0076] The ratio of 90 / 10 PGA / PLA fiber to polydioxanone (PDO) fiber in the non-woven fiber mat is 50:50, and the density is 1mg / cm 2 , manufactured by Concordia Manufacturing, LLC (Coventry, RI). A 15 cm by 15 cm GYNEMESH PS mesh (Ethicon Inc, Somerville, NJ) was sandwiched between the nonwoven fibrous batts by placing a nonwoven batt on each side of the mesh. The construct is then passed through a needle loom to engage the fiber batt to embed the mesh within the nonwoven mat. Two acupuncture passes were performed to generate the device. GYNEMESH PS mesh + (50:50) (90 / 10PGA / PLA): PDO nonwoven scaffold with a thickness of 0.97mm and a density of 60mg / cc.

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Abstract

Tissue engineering devices for pelvic floor repair are disclosed. More specifically, tissue engineering devices made of an implant, having a central portion at least partially embedded within a nonwoven felt are disclosed.

Description

technical field [0001] The present invention relates generally to the field of tissue repair and regeneration. More particularly, the present invention relates to devices for pelvic floor repair and methods of making the same. Background technique [0002] Individuals sometimes suffer tissue (eg, musculoskeletal) damage that requires surgical repair. Such repair can be accomplished by suturing the damaged tissue, and / or by fitting an implant into the damaged tissue. Implants can provide structural support to damaged tissue and can serve as a substrate on which cells can grow, facilitating more rapid healing. [0003] An example of a very common tissue injury is a pelvic floor injury. This is a potentially serious medical condition that may occur during or as a complication of childbirth, which may result in damage to the vesicovaginal fascia. This damage can lead to cystocele, a herniation of the bladder. Similar medical conditions include prolapse of the anus (rectal h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/00B32B5/26D04H13/00
CPCA61F2/0063D04H13/005A61F2250/0067D04H3/11D04H1/492A61F2210/0004B32B5/26A61F2/0045B32B5/022B32B5/026B32B5/08B32B7/12B32B2250/20B32B2262/0253B32B2262/0261B32B2262/0276B32B2262/06B32B2262/14B32B2307/72B32B2535/00
Inventor M·蒂默C·杨C·G·沃尔普J·J·哈默D·谢蒂D·J·基利J·J·唐纳斯
Owner ADVANCED TECH & REGENERATIVE MEDICINE
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