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Application of uvarilactam and aristololactam BI in preparation of anticancer medicaments

A technology of aristolochillactam and asterolactam, which is applied in the field of natural medicinal chemistry and medicine, and can solve problems such as the lack of anticancer activity of asterolactam

Inactive Publication Date: 2011-11-23
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there have been no reports on the anticancer activity of these two compounds, Ziyupan lactam and aristolactam BI

Method used

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  • Application of uvarilactam and aristololactam BI in preparation of anticancer medicaments
  • Application of uvarilactam and aristololactam BI in preparation of anticancer medicaments

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 In vitro anti-tumor activity experiment of Ziyu discolactam and aristolochlactam BI

[0016] 1. Experimental drugs:

[0017] Ziyupan lactam, aristolochillactam BI is isolated from the stems and branches of Uvaria microcarpa Champ.ex Benth., and the preparation method is detailed in [Xiang-Nan Yang( Yang Xiangnan), Yong-Sheng Jin (Jin Yongsheng), Ping Zhu (Zhu Ping) and Hai-Sheng Chenl (Chen Haisheng), AMIDES FROM Uvaria microcarpa Chemistry of Natural Compounds, 2010; 46(2): 324-326].

[0018] Control drug: doxycycline (DOX), Shijiazhuang Ruitian Biochemical Co., Ltd.

[0019] 2. Cell lines:

[0020] ①A549 (human lung adenocarcinoma cells); ②LOVO (human colon cancer cells) were provided by the Pharmacology Laboratory of Shanghai Institute of Pharmaceutical Industry

[0021] 3. Culture medium: RPMI1640+15%NBS+double antibody

[0022] 4 other materials

[0023] Fully automatic microplate reader: Model: (WellscanMK-2) Manufacturer: Labsystems

[0024] Impor...

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Abstract

Relating to the technical fields of natural medicinal chemistry and medicines, the invention specifically relates to the application of two aistololactam compounds-uvarilactam and aristololactam BI in preparation of anticancer medicaments. Cytotoxic activity experiments by a MTT (methyl thazolyl tetrazolium) method conducted in the invention show that, uvarilactam and aristololactam BI present obvious inhibiting effects on human lung cancer cells and human intestine cancer cells, so that uvarilactam and aristololactam BI can be used for preparing anticancer medicaments, thus providing a new source for the seeking of anticancer medicaments.

Description

technical field [0001] The present invention relates to the field of natural medicinal chemistry and medical technology, in particular to two phenanthrene lactam compounds isolated from the plant Ziyupan-uvarilactam (uvarilactam) and aristolactam BI (aristololactam BI ) for the preparation of anticancer drugs. Background technique [0002] Ziyupan is a plant of the genus Ziyupan (Uvaria microcarpa Champ.ex Benth.). Bitter, sweet, slightly warm. It has the functions of invigorating the stomach and promoting qi, expelling wind and relieving pain. For indigestion, abdominal distension and diarrhea, bruises, waist and leg pain. Plants of the genus Uvaria annonaceae contain alkaloids, flavonoids, annonaceae and polyoxosubstituted cyclohexene [Waterman PG, Mohammad I. Chemistry of the annonaceae. Structures of uvariindoles A-D, four new benzylated indole alkaloids from Uvariaangolensis[ J].Chem.Soc., Chem.Commun., 1984, 1280; Panichpol K, et al.WaighRD, and Waterman PG.Chondro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/404A61P35/00
Inventor 陈海生杨向楠金永生
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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