A kind of medicine for preventing and treating cardiotoxicity of anthracycline antibiotics and its application

A technology for cardiotoxicity and antibiotics, applied in the direction of antiviral agents, drug combinations, medical preparations containing active ingredients, etc., can solve the problems of high price, affecting the activity of doxorubicin malignant tumors, and use restrictions

Inactive Publication Date: 2011-12-14
SHANGHAI SIXTH PEOPLES HOSPITAL
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, studies have found that such drugs may cause severe myelosuppression, and may affect the activity of doxorubicin on certain malignant tumors. Therefore, the American Association of Clinical Oncology, Chemotherapy and Radiation Therapy Specialists has made a corresponding review on the clinical use of dexrazoxane Restrictions; secondly, drugs such as dexrazoxane are expensive, and can only be slowly pushed statically after being dissolved in lactic acid solution, and their use is greatly restricted

Method used

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  • A kind of medicine for preventing and treating cardiotoxicity of anthracycline antibiotics and its application
  • A kind of medicine for preventing and treating cardiotoxicity of anthracycline antibiotics and its application
  • A kind of medicine for preventing and treating cardiotoxicity of anthracycline antibiotics and its application

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Embodiment

[0029] Example (1): In vitro study on the protective effect of scutellarin on cardiomyocyte toxicity of adriamycin.

[0030] First, add FBS to DMEM to prepare medium, the concentration of FBS in the medium is 10%; rat H9c2 cardiomyocytes are diluted with medium to a concentration of 2×10 5 cells / mL of the cell suspension, and inoculated in 96-well culture plate, cultured for 24 hours, then treated with drugs. A blank control group, a medication group (containing 2 μM doxorubicin hydrochloride), and scutellarin solution groups of different concentrations (10, 25, 50, 100 μM) were set up respectively. After culturing for 48 hours, the MTT method was used to measure the absorbance at 570 nm using a microplate reader to calculate the cardiomyocyte activity.

[0031] refer to figure 1 Compared with the blank group with 100% cell viability, the cardiomyocyte viability was 41.18% at 2 μM doxorubicin hydrochloride, and after combined use of 10 μM, 25 μM, 50 μM and 100 μM scutellarin...

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Abstract

The invention relates to a drug for prevention and treatment of cardiotoxicity induced by anthracycline antibiotics, and an application thereof. Flavone can be adopted for preparing the drug for prevention and treatment of the cardiotoxicity induced by the anthracycline drugs after modifying a plurality of sites such as 3, 5, 6, 7, 3', 4' and the like on the chemical structural formula of the flavone. The experimental results show that: with the flavone compounds, the cardiotoxicity induced by adriamycin can be reduced, myocardial contraction function can be improved, and oxygen radicals can be removed; cardiac tissue overoxidation damage induced by the adriamycin can be reduced, and cardiac function can be improved; the cardiotoxicity to the human body induced by the anthracycline drugs during chemotherapy can be effectively reduced, the pain of the patient undergoing the chemotherapy can be reduced, and the death rate caused by the anthracycline drugs can be reduced.

Description

technical field [0001] The invention relates to a medicine for preventing and treating cardiotoxicity and its application, in particular to a substituted flavonoid compound used for preparing anthracycline antibiotic cardiotoxic medicine and its application. Background technique [0002] Doxorubicin, also known as doxorubicin (DOX), is an anthracycline antibiotic extracted from the light gray strain of Streptomyces lanusum. It can intercalate between DNA base pairs and tightly bind to DNA, preventing DNA dependence It interferes with the transcription process, inhibits the production of RNA, and can also prevent the replication of DNA. It is a non-specific drug for the cell cycle. Since its discovery in the 1860s, due to its strong anticancer effect and high chemotherapy index, doxorubicin has been one of the most effective antitumor drugs, and it is widely used clinically in various diseases such as leukemia, lymphoma, and solid cancer. The treatment of a kind of malignant...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P9/00A61P39/02A61P39/06
Inventor 郭澄万丽丽孙习鹏
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
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