Folic acid-containing targeted polymer drug carrier and preparation method thereof

A folic acid-targeted, high-molecular technology applied in the field of biomedicine to achieve good biocompatibility and good application prospects

Inactive Publication Date: 2011-12-14
JIANGXI SCI & TECH NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As for the FA-Pluronic-PLA block copolymer, there is no literature report yet

Method used

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  • Folic acid-containing targeted polymer drug carrier and preparation method thereof
  • Folic acid-containing targeted polymer drug carrier and preparation method thereof
  • Folic acid-containing targeted polymer drug carrier and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0024] A targeted polymer drug carrier containing folic acid--folic acid-polyoxyethylene-polyoxypropylene-polyoxyethylene-polylactic acid (FA-Pluronic-PLA) is prepared as follows. We use Pluronic F127 to synthesize FA- F127-PLA, the molecular formula of F127 is PEO 100 -PPO 65 -PEO 100 :

[0025] 1. Synthesis of FA-F127-OH: first add 0.42 g, 0.95 mmol FA and 0.18 g 1,3-dicyclohexylcarbodiimide (DCC) to 35 ml of anhydrous dimethyl sulfoxide (DMSO), in Stir at room temperature for 12 hours, then add 10 g, 0.79 mmol of Pluronic F127 and 0.097 g of 4-dimethylaminopyridine (DMAP), and continue stirring at room temperature for 24 hours. The reaction was then centrifuged for 5 minutes. The supernatant was dialyzed with DMSO for 3 hours, the molecular weight cut-off of the dialysis bag was 3500, and then dialyzed with twice distilled water for 24 hours. The reaction solution in the dialysis bag was spin-dried and dissolved in 5 ml of dichloromethane, dropped into anhydrous ether,...

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Abstract

The invention discloses an amphiphilic block polymer namely polymer folic acid-polyoxyethylene-polyoxypropylene-polyoxyethylene-polylactic acid (FA-Pluronic-PLA) which contains a folic acid targeting group, polyoxyethylene-polyoxypropylene-polyoxyethylene as a hydrophilic chain segment and polylactide as a hydrophobic chain segment and has a novel chemical structure, and a preparation method of the compound.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a targeted polymer drug carrier containing folic acid and a preparation method thereof. Background technique [0002] Amphiphilic polymers, especially biocompatible amphiphilic polymers (that is, polymers containing both hydrophilic and hydrophobic segments) have been extensively studied because they can pass through the interaction between hydrophobic segments in water. Self-aggregation such as hydrophobic interaction forms nanoparticles with various morphologies. This property makes amphiphilic polymers have great application prospects in drug delivery systems, such as controllable release systems and targeted release systems. We know that most of the current drugs (such as anticancer drugs) are hydrophobic, that is, insoluble in water, and are easily excreted by a series of rejection reactions in the human body, such as drug resistance, enzyme degradation, etc., which greatly Limiting...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/685A61K47/34A61P35/00
Inventor 熊向源郭亮李资玲龚妍春李玉萍
Owner JIANGXI SCI & TECH NORMAL UNIV
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