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Gip-increase inhibitor

一种抑制剂、制剂的技术，应用在新的GIP升高抑制剂领域，能够解决GIP功能抑制效果没有得到证实、抑制GIP分泌的效果没有研究、效果不总是令人满意等问题

Inactive Publication Date: 2013-11-06
KAO CORP
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] However, the problem is that the inhibitory effect of the former substance on GIP function in vivo has not been confirmed, and the effect of the latter substance on inhibiting GIP secretion when lipid intake has not been studied , Moreover, the above-mentioned substances are not always satisfactory in their effects of improving gastric indigestion, etc., and therefore substances that can be safely ingested in daily life and have more excellent effects are required
[0005]However, there is no report on the relationship between rice bran extract and GIP, especially between rice bran oil and GIP

Method used

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Examples

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Embodiment 1

[0055] (Preparation of rice bran extract)

[0056] (1) 1.8 kg of rice bran prepared from Koshihikari produced by Tochigi prefecture was freeze-dried, and 9 L of n-hexane was added to the freeze-dried product, followed by stirring for 3 hours to conduct extraction. The extract was filtered, and the residue was further extracted twice with 9 L of n-hexane each time. Extracts obtained by a total of 3 extractions were mixed, the resultant was concentrated and dried to harvest 372 g of rice bran extract.

[0057] (2) To 20 g of the rice bran extract obtained in the above process (1), 15 mL of water and 20 mg of lipase OF (manufactured by Meito Sangyo Co., Ltd.) were added, and the mixture was stirred at 50° C. for 15 hours. Subsequently, the water layer was removed by centrifugation, and the oil layer was subjected to distillation and deacidification under conditions of 220° C. and 13.3 Pa, thereby harvesting 3.2 g of component-enriched oil.

[0058] (3) A rice bran extract ("ORY...

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Abstract

A GIP-increase inhibitor, which is useful as a drug or a food, comprising a rice bran extract as an active ingredient.

Description

technical field [0001] The present invention relates to a novel inhibitor of GIP elevation. Background technique [0002] Gastric inhibitory polypeptide (Gastric inhibitory polypeptide, GIP) is known to be the gastrointestinal hormone that has the function of suppressing gastric acid secretion and gastric motility. When eating, lipids in the diet, etc. can cause its secretion to be hyperactive (non-patent documents 1-3 ). Therefore, it can be considered that substances that inhibit the secretion of GIP have an effect on promoting digestion and improving gastric accumulation. According to research so far, 3-bromo-5-methyl-2-phenylpyrazol[1,5-a]pyrimidin-7-ol (BMPP) is known as a substance that inhibits GIP function, and as a substance that inhibits GIP secretion Guar gum and the like are known (Patent Document 1, Non-Patent Documents 4 to 9). [0003] However, the problem is that the inhibitory effect of the former substance on GIP function in the body has not been confirm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/88A61P1/00
CPCA61K36/88A61P1/00A61P1/14A61P43/00
Inventor 福冈大介桥爪浩二郎下丰留玲
Owner KAO CORP
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